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Intensive longitudinal designs involving repeated assessments of constructs often face the problems of nonignorable attrition and selected omission of responses on particular occasions. However, time series models, such as vector autoregressive (VAR) models, are often fit to these data without consideration of nonignorable missingness. We introduce a Bayesian model that simultaneously represents the over-time dependencies in multivariate, multiple-subject time series data via a VAR model, and possible ignorable and nonignorable missingness in the data. We provide software code for implementing this model with application to an empirical data set. Moreover, simulation results comparing the joint approach with two-step multiple imputation procedures are included to shed light on the relative strengths and weaknesses of these approaches in practical data analytic scenarios.
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http://dx.doi.org/10.1080/10705511.2019.1623681 | DOI Listing |
Psychol Methods
August 2025
Department of Psychology, University of Minnesota.
The statistical and pragmatic tension between explanation and prediction is well recognized in psychology. Yarkoni and Westfall (2017) suggested focusing more on predictions, which will ultimately produce better calibrated interpretations. Variable selection methods, such as regularization, are strongly recommended because it will help construct interpretable models while optimizing prediction accuracy.
View Article and Find Full Text PDFStat Biopharm Res
July 2024
Department of Biostatistics, University of North Carolina at Chapel Hill.
Deep Learning (DL) methods have dramatically increased in popularity in recent years. While its initial success was demonstrated in the classification and manipulation of image data, there has been significant growth in the application of DL methods to problems in the biomedical sciences. However, the greater prevalence and complexity of missing data in biomedical datasets present significant challenges for DL methods.
View Article and Find Full Text PDFJ Am Stat Assoc
June 2024
Yau Mathematical Sciences Center, Tsinghua University.
Mediation analysis is widely used for investigating direct and indirect causal pathways through which an effect arises. However, many mediation analysis studies are challenged by missingness in the mediator and outcome. In general, when the mediator and outcome are missing not at random, the direct and indirect effects are not identifiable without further assumptions.
View Article and Find Full Text PDFContemp Clin Trials
May 2025
Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America. Electronic address:
Non-ignorable missing data arise often in clinical trials. The VEST trial, a randomized, within-patient-controlled study, assessed the effect of an external scaffold for saphenous vein grafts on intimal hyperplasia (IH) one year after coronary artery bypass graft surgery. It was anticipated that approximately 13 % of grafts would be occluded and unsuitable for intravascular ultrasound, resulting in missing IH values at 1-year.
View Article and Find Full Text PDFStat Med
February 2025
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stepped wedge cluster-randomized trial (CRTs) designs randomize clusters of individuals to intervention sequences, ensuring that every cluster eventually transitions from a control period to receive the intervention under study by the end of the study period. The analysis of stepped wedge CRTs is usually more complex than parallel-arm CRTs due to more complex intra-cluster correlation structures. A further challenge in the analysis of closed-cohort stepped wedge CRTs, which follow groups of individuals enrolled in each period longitudinally, is the occurrence of dropout.
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