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The acquisition and representation of natural numbers have been a central topic in cognitive science. However, a key question in this topic about how humans acquire the capacity to understand that numbers make 'infinite use of finite means' (or that numbers are generative) has been left unanswered. While previous theories rely on the idea of the successor principle, we propose an alternative hypothesis that children's understanding of the syntactic rules for building complex numerals-or numerical syntax-is a crucial foundation for the acquisition of number concepts. In two independent studies, we assessed children's understanding of numerical syntax by probing their knowledge about the embedded structure of cardinal numbers using a novel task called Give-a-number Base-10 (Give-N10). In Give-N10, children were asked to give a large number of items (e.g., 32 items) from a pool that is organized in sets of ten items. Children's knowledge about the embedded structure of numbers (e.g., knowing that thirty-two items are composed of three tens and two ones) was assessed from their ability to use those sets. Study 1 tested English-speaking 4- to 10-year-olds and revealed that children's understanding of the embedded structure of numbers emerges relatively late in development (several months into kindergarten), beyond when they are capable of making a semantic induction over a local sequence of numbers. Moreover, performance in Give-N10 was predicted by other task measures that assessed children's knowledge about the syntactic rules that govern numerals (such as counting fluency), demonstrating the validity of the measure. In Study 2, this association was tested again in monolingual Korean kindergarteners (5-6 years), as we aimed to test the same effect in a language with a highly regular numeral system. It replicated the association between Give-N10 performance and counting fluency, and it also demonstrated that Korean-speaking children understand the embedded structure of cardinal numbers earlier in the acquisition path than English-speaking peers, suggesting that regularity in numerical syntax facilitates the acquisition of generative properties of numbers. Based on these observations and our theoretical analysis of the literature, we propose that the syntax for building complex numerals, not the successor principle, represents a structural platform for numerical thinking in young children.
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http://dx.doi.org/10.1016/j.cognition.2020.104331 | DOI Listing |
J Med Internet Res
September 2025
Department of Community Medicine, Faculty of Health, UiT The Arctic University of Norway, Tromsø, Norway.
Background: The ability to access and evaluate online health information is essential for young adults to manage their physical and mental well-being. With the growing integration of the internet, mobile technology, and social media, young adults (aged 18-30 years) are increasingly turning to digital platforms for health-related content. Despite this trend, there remains a lack of systematic insights into their specific behaviors, preferences, and needs when seeking health information online.
View Article and Find Full Text PDFPLoS One
September 2025
School of Mechanical and Automotive Engineering, Qingdao University of Technology, Qingdao, Shandong, China.
Drug-target interaction (DTI) prediction is essential for the development of novel drugs and the repurposing of existing ones. However, when the features of drug and target are applied to biological networks, there is a lack of capturing the relational features of drug-target interactions. And the corresponding multimodal models mainly depend on shallow fusion strategies, which results in suboptimal performance when trying to capture complex interaction relationships.
View Article and Find Full Text PDFJ Histotechnol
September 2025
3d.FAB, Université Claude Bernard Lyon 1, CNRS, INSA, CPE-Lyon, Villeurbanne, France.
Histological preparation paraffin embedding is the gold standard method for evaluating tissue structure and composition, whether it is originated from biopsy or engineered . Quite often, deformation and shrinkage occur during the histological preparation, which are difficult to predict and qualify. The present study investigates the morphometric changes in bioprinted hydrogels composed of alginate and gelatine, common tissue engineering materials, focusing on three morphologies: full slabs, porous slabs, and porous cubes.
View Article and Find Full Text PDFDiscov Nano
September 2025
Department of Rehabilitation Medicine, Rehabilitation Medical Center, Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Immunoelectron Microscopy (IEM) is a technique that combines specific immunolabeling with high-resolution electron microscopic imaging to achieve precise spatial localization of biomolecules at the subcellular scale (< 10 nm) by using high-electron-density markers such as colloidal gold and quantum dots. As a core tool for analyzing the distribution of proteins, organelle interactions, and localization of disease pathology markers, it has irreplaceable value, especially in synapse research, pathogen-host interaction mechanism, and tumor microenvironment analysis. According to the differences in labeling sequence and sample processing, the IEM technology system can be divided into two categories: the first is pre-embedding labeling, which optimizes the labeling efficiency through the pre-exposure of antigenic epitopes and is especially suitable for the detection of low-abundance and sensitive antigens; the second is post-embedding labeling, which relies on the low-temperature resin embedding (e.
View Article and Find Full Text PDFTheor Appl Genet
September 2025
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany.
The German Federal Ex Situ Genebank for Agricultural and Horticultural Crops (IPK) harbours over 3000 pea plant genetic resources (PGRs), backed up by corresponding information across 16 key agronomic and economical traits. The unbalanced structure and inconsistent format of this historical data has precluded effective leverage of genebank accessions, despite the opportunities contained in its genetic diversity. Therefore, a three-step statistical approach founded in linear mixed models was implemented to enable a rigorous and targeted data curation.
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