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. The purpose of this article was to determine how characteristics of bimanual coordination tasks affect the quality of performance and to determine the impact of these characteristics on muscular activation of the upper limbs, with consideration of age-related differences. . The research was carried out on two groups consisting of 25 people aged 20-30 and 60-67 years. The subjects performed seven tasks that varied in coordination mode, tracking mode and outline-tracing. The main measures of task performance were calculated on the basis of the difference between the position of the target and tracing cursors. Cohen's value was calculated to show differences in measures between groups. . There were higher values of error and variability measures for elderly people compared to young. Complex tasks showed the largest difficulty, which suggests that, when performed, such tasks have the greatest potential to improve coordination skills. Tasks during which both limbs contribute to the movement of one cursor proved the most appropriate. . The tracking mode is of great importance for the quality of performance in motor coordination tasks, while the performance of tasks with imposed speed is much more strongly age-sensitive than performance with a freely chosen speed.
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http://dx.doi.org/10.1080/10803548.2020.1759296 | DOI Listing |
Alzheimers Dement
September 2025
Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea.
Introduction: We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.
Methods: We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data.
Front Genet
August 2025
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States.
Introduction: Aging is accompanied by systemic metabolic changes that contribute to disease susceptibility and functional decline. Sex differences in aging have been reported in humans, yet their mechanistic basis remains poorly understood. Due to their physiological similarity to humans, rhesus macaques are a powerful translational model to investigate sex-specific metabolomic aging under controlled conditions.
View Article and Find Full Text PDFClin Interv Aging
September 2025
Department for Orthopedics, Traumatology and Plastic Surgery, University Hospital, Leipzig, Germany.
Study Design: Systematic review.
Purpose: As the number of elderly increases, age-related changes of body composition like osteoporosis and sarcopenic muscle changes contribute to higher morbidity, less quality of life and higher health care costs. Data on the effect of muscle atrophy on osteoporotic vertebral fractures is limited.
Front Vet Sci
August 2025
Department of Musculoskeletal Biology and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Body composition metrics such as bodyweight, body condition score (BCS) and muscle condition score (MCS) can be readily recorded as part of veterinary examinations in ageing cats. However, the description of how these parameters change with age, whilst accounting for sex and age-related morbidity, is limited. The aim of this prospective cohort study was to evaluate age, sex and health-related changes in bodyweight, BCS and MCS in client-owned pet cats.
View Article and Find Full Text PDFParkinsonism Relat Disord
September 2025
Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland. Electronic address:
Introduction: Sarcopenia, the age-related loss of muscle mass and function, has been reported in Parkinson's disease (PD). While grip strength is a key marker of sarcopenia and has been linked to PD risk and progression, its relationship with underlying neurodegenerative processes remains unclear. This study examines whether grip strength is impaired in PD and reflects disease severity or dopaminergic function.
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