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When solving constrained multiobjective optimization problems (CMOPs), the most commonly used way of measuring constraint violation is to calculate the sum of all constraint violations of a solution as its distance to feasibility. However, this kind of constraint violation measure may not reflect the distance of an infeasible solution from feasibility for some problems, for example, when an infeasible solution closer to a feasible region does not have a smaller constraint violation than the one farther away from a feasible region. Unfortunately, no set of artificial benchmark problems focusing on this area exists. To remedy this issue, a set of CMOPs with deceptive constraints is introduced in this article. It is the first attempt to consider CMOPs with deceptive constraints (DCMOPs). Based on our previous work, which designed a set of directed weight vectors to solve CMOPs, this article proposes a cooperative framework with an improved version of directed weight vectors to solve DCMOPs. Specifically, the cooperative framework consists of two switchable phases. The first phase uses two subpopulations-one to explore feasible regions and the other to explore the entire space. The two subpopulations provide useful information about the optimal direction of objective improvement to each other. The second phase aims mainly at finding Pareto-optimal solutions. Then an infeasibility utilization strategy is used to improve the objective function values. The two phases are switchable based on the information found to date at any time in the evolutionary process. The experimental results show that this method significantly outperforms the algorithms with which it is compared on most of the DCMOPs, in terms of reliability and stability in finding a set of well-distributed optimal solutions.
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http://dx.doi.org/10.1109/TCYB.2020.2998038 | DOI Listing |
Mol Psychiatry
September 2025
Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Pharmacological modulation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) through dual GIP/GLP-1 receptor agonists, commonly used for diabetes and obesity, shows promise in reducing alcohol consumption. We applied drug-target Mendelian randomization (MR) using genetic variation at these loci to assess their long-term effects on problematic alcohol use (PAU), binge drinking, alcohol misuse classifications, liver health, and other substance use behaviors. Genetic proxies for lowered BMI, modeling the appetite-suppressing and weight-reducing effects of variants in both the GIPR and GLP1R loci ("GIPR/GLP1R"), were linked with reduced binge drinking in the primary (β = -0.
View Article and Find Full Text PDFNat Med
September 2025
Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Existing evaluations of the National Health Service Diabetes Prevention Programme (NHS DPP) in England have demonstrated associated reductions in body weight, hemoglobin A1c and incident type 2 diabetes (T2D). In this study, we examined associations between completion of the NHS DPP and incidence of T2D and 30 other long-term conditions (LTCs), including LTCs considered linked to the program's interventional goals of body weight reduction, increased physical activity and improved diet quality (LTC-L) and LTCs considered to be possibly linked to those goals (LTC-PL). We found that completers of the NHS DPP had lower incidences of T2D, LTC-L and LTC-PL compared to non-attenders.
View Article and Find Full Text PDFInt Heart J
September 2025
Department of Cardiovascular Surgery, West China Hospital, Sichuan University.
Although several observational studies have suggested an association between plasma homocysteine (Hcy), vitamin B12, and folate levels and aortic diseases, including aortic dissection (AD), thoracic aortic aneurysm (TAA), and abdominal aortic aneurysm (AAA), the causality remains unclear. The aortic diameter was also included in the analysis. Therefore, this study employed Mendelian randomization (MR) analysis to investigate the effects of plasma Hcy, vitamin B12, and folate levels on aortic diseases.
View Article and Find Full Text PDFPerfusion
September 2025
Cardiac Surgery Department, Bristol Royal Children's Hospital, Bristol, UK.
BackgroundDuring cardiopulmonary bypass (CPB), goal-directed perfusion (GDP) seeks to match oxygen delivery to metabolic demand, but the dynamics of oxygen extraction and intraoperative oxygen demand remain poorly understood, especially in paediatric populations. Existing models rely on limited data and assume, for example, a linear relationship between log oxygen demand and temperature.MethodsWe developed GARIX (Global AutoRegressive Integrated model with eXogenous variables and an equilibrium force) to predict minute-by-minute changes in oxygen extraction ratio (OER) using high-resolution intraoperative data.
View Article and Find Full Text PDFPharmacol Res
September 2025
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address:
The valine catabolite 3-hydroxyisobutyrate (3-HIB) is suggested to mediate the uptake of extracellular fatty acids into the cells, thus regulating intracellular lipid metabolism, although the direct mechanism remains unclear. In this study, we assessed the effects of long-term 3-HIB treatment on the development and progression of complex atherosclerotic lesions, lipid metabolism and liver injury in vivo in ApoE-/- mouse model fed Western Diet (WD). Results show that 3-HIB treatment is associated with a significant reduction in weight and serum lipid content, reduced aortic mean plaque area and improvement of liver functions.
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