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Purpose: This study aimed to develop cadence-based metabolic equations (CME) for predicting the intensity of level walking and evaluate these CME against the widely adopted American College of Sports Medicine (ACSM) Metabolic Equation, which predicts walking intensity from speed and grade.
Methods: Two hundred and thirty-five adults (21-84 yr of age) completed 5-min level treadmill walking bouts between 0.22 and 2.24 m·s, increasing by 0.22 m·s for each bout. Cadence (in steps per minute) was derived by dividing directly observed steps by bout duration. Intensity (oxygen uptake; in milliliters per kilogram per minute) was measured using indirect calorimetry. A simple CME was developed by fitting a least-squares regression to the cadence-intensity relationship, and a full CME was developed through best subsets regression with candidate predictors of age, sex, height, leg length, body mass, body mass index (BMI), and percent body fat. Predictive accuracy of each CME and the ACSM metabolic equation was evaluated at normal (0.89-1.56 m·s) and all (0.22-2.24 m·s) walking speeds through k-fold cross-validation and converted to METs (1 MET = 3.5 mL·kg·min).
Results: On average, the simple CME predicted intensity within ~1.8 mL·kg·min (~0.5 METs) at normal walking speeds and with negligible (<0.01 METs) bias. Including age, leg length, and BMI in the full CME marginally improved predictive accuracy (≤0.36 mL·kg·min [≤0.1 METs]), but may account for larger (up to 2.5 mL·kg·min [0.72 MET]) deviations in the cadence-intensity relationships of outliers in age, stature, and/or BMI. Both CME demonstrated 23%-35% greater accuracy and 2.2-2.8 mL·kg·min (0.6-0.8 METs) lower bias than the ACSM metabolic equation's speed-based predictions.
Conclusions: Although the ACSM metabolic equation incorporates a grade component and is convenient for treadmill-based applications, the CME developed herein enables accurate quantification of walking intensity using a metric that is accessible during overground walking, as is common in free-living contexts.
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http://dx.doi.org/10.1249/MSS.0000000000002430 | DOI Listing |
PLoS One
September 2025
Department of Mathematics and Statistics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
This research explores the dynamical properties and solutions of actin filaments, which serve as electrical conduits for ion transport along their lengths. Utilizing the Lie symmetry approach, we identify symmetry reductions that simplify the governing equation by lowering its dimensionality. This process leads to the formulation of a second-order differential equation, which, upon applying a Galilean transformation, is further converted into a system of first-order differential equations.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Objective: This study investigates the mechanisms behind exercise capacity in adults with type 2 diabetes mellitus (T2DM), focusing on central and peripheral components, as described by the Fick equation.
Methods: A cross-sectional study of 141 adults with T2DM was conducted, using cardiopulmonary exercise testing, near-infrared spectroscopy (NIRS) and exercise echocardiography. Participants with sufficient-quality NIRS data were stratified into tertiles based on percentage predicted VO₂peak.
PLoS One
September 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.
Background: Maternal childhood maltreatment has been associated with higher risk of adverse neurodevelopment in offspring. Chronic systemic inflammation has been associated with childhood maltreatment and has been identified as a gestational risk factor for adverse neurodevelopment in offspring. Thus, inflammation may be a mechanism by which maternal exposure to maltreatment affects offspring neurodevelopment.
View Article and Find Full Text PDFJ Obes Metab Syndr
September 2025
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: This study explores how relative skeletal muscle mass is associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and the remission of baseline MASLD in a community-based population cohort.
Methods: The study included 1,544 participants with an average age of 58 years. All participants underwent baseline and follow-up assessments in 2015 or 2016.
J Environ Manage
September 2025
Key Lab of Basin Water Resource and Eco-Environmental Science in Hubei Province, Basin Water Environmental Research Department, Changjiang River Scientific Research Institute, No.23 Huangpu Road, Wuhan, 430010, PR China; Innovation Team for Basin Water Environmental Protection and Governance of Chan
Small cascade dams drive spatial divergence in the composition of dissolved organic matter (DOM) in local sediments. Taking Xixi River in the southeast of China, a representative small cascade-dammed watershed, as an example, this study explored the spatial variations of DOM components and its interactions with microbial communities under the influence of cascade dams. Results revealed that DOM composition differed significantly, i.
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