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http://dx.doi.org/10.1016/j.jid.2020.03.937 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Infectious Diseases, Third People's Hospital of Chengdu, Chengdu, China.
Rationale: Japanese spotted fever (JSF) is a rare tick-borne disease caused by Rickettsia japonica. Atypical manifestations and a lack of standardized diagnostic assays often result in delayed diagnosis and treatment, potentially leading to life-threatening complications.
Patient Concerns: A 57-year-old immunocompetent female from a region with no previously reported JSF cases presented with acute-onset high-grade fever (39.
Photodiagnosis Photodyn Ther
September 2025
China Medical University, Hsin-Chu Hospital. Electronic address:
Background: Managing stage IV thymoma with pleural spread or recurrence remains a complex clinical challenge. While complete resection is considered essential for achieving long-term survival, its feasibility and outcomes vary. Inspired by surgical strategies used in malignant pleural mesothelioma, we applied a multimodal approach combining extensive thymectomy, cytoreductive lung-preserving pleurectomy/decortication, and intraoperative photodynamic therapy (PDT) to enhance local control and survival outcomes.
View Article and Find Full Text PDFCureus
July 2025
Academic Department of Endocrinology, Diabetes and Infectiology, Klinikum Bielefeld, Medical School and University Medical Centre East Westphalia-Lippe Bielefeld University, Bielefeld, DEU.
The simultaneous occurrence of Addison's disease and acromegaly presents a unique and complex clinical challenge. Addison's disease, characterized by autoimmune adrenal destruction, results in cortisol and aldosterone deficiencies, while acromegaly stems from excessive growth hormone secretion, usually due to a pituitary adenoma. Their coexistence complicates diagnosis and management due to overlapping systemic effects.
View Article and Find Full Text PDFPrim Care
September 2025
Department of Community and Family Medicine, University Health Lakewood Medical Center, University of Missouri Kansas City School of Medicine, Kansas City, MO, USA.
Disorders of pigmentation encompass a wide range of conditions categorized into hyperpigmentation, hypopigmentation, and depigmentation, each with distinct etiologies, clinical presentations, and implications. This article outlines the pathophysiology, clinical features, diagnostic approaches, and management strategies for these pigmentary disorders for primary care physicians. Recognizing systemic associations and rare presentations is also essential for primary care physicians to diagnose and guide treatment or dermatologic referral.
View Article and Find Full Text PDFJ Cosmet Dermatol
August 2025
Department of Dermatology, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Background: Exosomes are extracellular vesicles produced by virtually all cell types. In dermatology, exosomes have garnered significant attention for their potential applications in skin restoration and rejuvenation. Despite their widespread marketing in aesthetic medicine, no exosome product is currently approved for dermal injection, and their safety profile remains unclear.
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