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Six new -inositol derivatives (-) were isolated from the leaves of collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound exhibited potent inhibitory activity for NO production with an IC value of 7.1 μM.
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http://dx.doi.org/10.1021/acs.jnatprod.9b01239 | DOI Listing |
Biotechnol Lett
September 2025
The United Graduate School of Agricultural Science, Iwate University, Ueda-3, Morioka, Iwate, 020-8550, Japan.
Plasmalogens are a subclass of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position; they play several physiological roles including membrane stabilization, antioxidant activity, and signal transduction. While choline, ethanolamine, serine, and glycerol plasmalogens (PlsCho, PlsEtn, PlsSer, and PlsGro) are naturally abundant, inositol plasmalogens (PlsIns) are rare. In contrast to the limited occurrence of PlsIns, phosphatidylinositol is a biologically crucial lipid, and its enzymatic biosynthesis from phosphatidylcholine has been extensively studied.
View Article and Find Full Text PDFBiosens Bioelectron
August 2025
Department of Chemical Science and Technologies, University of Rome "Tor Vergata", Via Della Ricerca Scientifica, 00133, Rome, Italy; SENSE4MED, via Bitonto 139, 00133, Rome, Italy. Electronic address:
Phytic acid is a phosphorylated derivative of myo-inositol that is ubiquitous in plants and serves as the primary storage form of phosphorus. In human nutrition, phytic acid is considered an anti-nutrient because it chelates essential minerals, including calcium, iron, and zinc. This binding action reduces the bioavailability of these metals, highlighting the importance of monitoring phytic acid in food.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
College of Plant Protection, Yangzhou University, 225009 Yangzhou, PR China. Electronic address:
The brown planthopper (BPH), Nilaparvata lugens (Stål), is a typical insecticide-induced resurgence rice pest that causes severe damage to rice in Asian countries. Previous studies have shown that the fungicide Jinggangmycin (JGM), used to control rice sheath blight disease, can stimulate BPH fecundity; however, the molecular mechanism remains to be further explored. In this study, based on transcriptomic analysis, we found that the PI3K-Akt signaling pathway was significantly enriched in BPH after feeding on JGM-treated rice, where the NlPR-L and NlABD4-L genes were significantly upregulated.
View Article and Find Full Text PDFUnlabelled: Triple-negative breast cancer (TNBC) remains a significant clinical challenge due to its aggressive nature and lack of effective targeted therapies. The enzyme ceramide synthase 2 (CerS2), which synthesizes pro-apoptotic very long-chain ceramides (VLCCs), represents a promising therapeutic target. Here, we identify and characterize DH20931, a novel, first-in-class small-molecule agonist of CerS2.
View Article and Find Full Text PDFActa Pharm Sin B
August 2025
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Acute liver failure (ALF) is a life-threatening condition associated with macrophage-mediated inflammatory responses. Effective therapies and drugs are still lacking to date. Here, we reveal that a derivative of xanthohumol, CAM12203, alleviates lipopolysaccharide (LPS) + d-galactosamine (D-GalN)-induced ALF through limiting macrophage-mediated inflammation, with the most significant impact on interleukin-1 (IL-1) transcription.
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