Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
An important challenge in Parkinson's disease (PD) based neuroscience and neuroimaging is mapping the neuronal connectivity of the basal ganglia to understand how the disease affects brain circuitry. However, a majority of diffusion tractography studies have shown difficulties in revealing connections between distant anatomic brain regions and visualizing basal ganglia connectome. In this current study, we investigated the differences in basal ganglia connectivity between 6-OHDA induced PD mouse model and normal mouse model by using diffusion tensor imaging tractography from diffusion-weighted images obtained with a high resolution 9.4 T MR scanner. Connectivity pattern of the basal ganglia were compared between five 6-OHDA and five control mouse brains using results of probabilistic tractography generated with PROBTRACKX. When compared with control mouse, 6-OHDA mouse showed significant enhancements to motor territory-related subthalamopallidal and pallido-subthalamic connectivity. Multi-fiber tractography combined with diffusion MRI data has the potential to help recognize the abnormalities found in connectivity of psychiatric and neurologic disease models.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075660 | PMC |
| http://dx.doi.org/10.5607/en.2020.29.1.80 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mental and behavioral abnormalities caused by occlusion of the right coronary artery: A case report.
Medicine (Baltimore)
September 2025
Department of Intensive Care Unit, The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan City, Guangdong Province, China.
Rationale: Mental and behavioral abnormalities are difficult neurological conditions, and the site of the lesion may involve the basal ganglia. Its etiology is varied and requires a detailed differential diagnosis.
Patient Concerns: An 81-year-old woman had a history of "cerebral infarction" for 5 years.
Older and wiser? The neural correlates of worry induction and reappraisal in older adults.
Neuropsychopharmacology
September 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Severe worry is a transdiagnostic, highly prevalent symptom, difficult to treat and associated with significant morbidity in late life. Understanding the neural correlates of worry induction and reappraisal in older adults is key to developing novel treatments. We recruited 124 older adults ( ≥ 50 years old) with varying worry severity and clinical comorbidity (27% generalized anxiety disorder, 23% depressive disorders).
View Article and Find Full Text PDFPresynaptic and postsynaptic determinants of claustro-cortical connectivity.
Curr Biol
July 2025
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:
The claustrum (CLA) is a thin and elongated brain structure that is located between the insula and lateral striatum and is implicated in a wide range of behaviors. It is characterized by its extensive synaptic connectivity with multiple cortical regions. While CLA projection neurons are glutamatergic, several studies have shown an inhibitory impact of CLA on its cortical targets, suggesting the involvement of inhibitory cortical interneurons.
View Article and Find Full Text PDFDistinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants.
Eur J Neurol
September 2025
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: Frontotemporal dementia (FTD) encompasses diverse clinical phenotypes, primarily characterized by behavioral and/or language dysfunction. A newly characterized variant, semantic behavioral variant FTD (sbvFTD), exhibits predominant right temporal atrophy with features bridging behavioral variant FTD (bvFTD) and semantic variant primary progressive aphasia (svPPA). This study investigates the longitudinal structural MRI correlates of these FTD variants, focusing on cortical and subcortical structural damage to aid differential diagnosis and prognosis.
View Article and Find Full Text PDFA human striatal-midbrain assembloid model of alpha-synuclein propagation.
Brain
September 2025
Okinawa Institute of Science and Technology Graduate University, Okinawa, 904-0495, Japan.
Animal models of the pathology of Parkinson's disease (PD) have provided most of the treatments to date, but the disease is restricted to human patients. In vitro models using human pluripotent stem cells (hPSCs)-derived neural organoids have provided improved access to study PD etiology. This study established a method to generate human striatal-midbrain assembloids (hSMAs) from hPSCs for modeling alpha-synuclein (α-syn) propagation and recapitulating basal ganglia circuits, including nigrostriatal and striatonigral pathways.
View Article and Find Full Text PDF