Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Exposure to brain injury via blast or blunt mechanisms disrupts multiple sensorimotor systems simultaneously. Large numbers of US Gulf War era and Operation Iraqi/Enduring Freedom veterans with traumatic brain injury (TBI) are suffering the symptom of dizziness - presumed due to "Multi-Sensory Impairment", a clinical pattern of damage to the auditory, visual and vestibular sensorimotor systems.
Objective: To describe the oculomotor response to rapid head rotation in a population of veterans with dizziness. We also describe the reliability of using the video head impulse test (vHIT) in a veteran population.
Methods: We used the vHIT to evaluate the vestibular-ocular reflex (VOR) gain and presence of compensatory saccades (CS) in each semicircular canal of 81 veterans (31% TBI) with dizziness. Data was collected using the ICS Otometric™ vHIT. Data was processed using both the Otometric™ software and custom software written in MATLAB™. This data was evaluated through Kruskal-Wallis rank-sum test and analysis of regression.
Results: Veterans with dizziness recruit CS in all semicircular canal planes even though their VOR gain is normal. The vHIT is a reliable clinical test to quantify the metrics of the VOR and CS in veterans.
Conclusion: Veterans with dizziness symptoms use compensatory saccades in all planes of semicircular canal rotation, despite having normal peripheral VOR gain during rapid head rotation. The video head impulse test is a stable measure of vestibular slow phase and metrics of compensatory saccades in veterans with dizziness.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3233/VES-200692 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Objective: Traumatic brain injury affects 1.5 million people per year in the United States, with the majority classified as mild (mTBI). While many immediate symptoms are limited to the short-term, some patients experience long-term daily impairments in function and quality of life.
View Article and Find Full Text PDFA dose-finding study shows terazosin enhanced energy metabolism in neurologically healthy adults.
J Parkinsons Dis
August 2025
Department of Neurology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
BackgroundParkinson's disease (PD) is a common neurodegenerative disease lacking treatments that modify progressive neuron loss. Terazosin (TZ) increases activity of the glycolytic enzyme phosphoglycerate kinase 1 and could potentially benefit impaired brain bioenergetics in PD. Preclinical data are encouraging, but we lack human data on relationships between TZ dose and measures of TZ target engagement in women and men.
View Article and Find Full Text PDFSalvage boron neutron capture therapy for recurrent intracranial malignant meningioma: Case report and literature review.
Medicine (Baltimore)
August 2025
Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan.
Rationale: Meningiomas are the most common central nervous system tumors in adults, accounting for approximately one-third of the total. Although only 1% to 3% of meningiomas are malignant, these cases exhibit a high degree of aggression and frequent recurrence, resulting in a poor prognosis. There are no accepted treatment standards for salvage re-irradiation.
View Article and Find Full Text PDFAdvanced Patient Selection for Percutaneous Transluminal Angioplasty and Stenting for Severe Symptomatic Stenosis of the Subclavian Artery: Quantitative Evaluation with DHI and SF-36 Questionnaires.
World Neurosurg
July 2025
Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Neuroscience Research Center, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address:
Objective: This study was designed to quantitatively evaluate the clinical effectiveness of percutaneous transluminal angioplasty and stenting (PTAS) in patients with severe symptomatic stenosis of the subclavian artery (SSS/SA) via the Dizziness Handicap Inventory (DHI) and SF-36 questionnaires.
Methods: This was a reanalysis of a prospective, single-center study which was conducted from 2015 to 2024. The inclusion criteria were 1) patients who had significant stenosis (≧70%) of a single SA, 2) medically refractory symptoms, 3) abnormal blood flow patterns in the ipsilateral vertebral artery on dynamic sonographic images, and 4) no other possible causes of dizziness.
Bidirectional Association Between Peripheral Vestibular Disorders and Depressive Disorders: A Longitudinal Follow-Up Study.
J Acad Consult Liaison Psychiatry
July 2025
Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:
Background: An increasing body of evidence indicates that peripheral vestibular disorders (PVDs) are associated with depressive disorders. However, further investigation is required to elucidate the temporal and causal relationships between the aforementioned disorders.
Objective: To clarify the bidirectional association between peripheral vestibular disorders and depressive disorders.