Impact of lesion calcification and hardness on periprocedural brain ischemia in patients with intracranial atherosclerotic disease undergoing angioplasty and stenting.

Objectives: To evaluate the risk factors for periprocedural brain ischemic lesions (PBILs) in patients with severe intracranial arterial stenosis (ICAS) treated with percutaneous transluminal angioplasty and stenting (PTAS).

Methods: We analyzed the data of a prospectively collected cohort of patients with severe ICAS in whom aggressive medical treatment had failed and who underwent PTAS with intracranial stents. Lesion calcification was identified on CT.

Molecular insights into the mechanism between the structural and mechanical properties of glycol chitosan methacrylate hydrogels.

Glycol chitosan (GC), a derivative of chitosan with ethylene glycol branches, is favored in pharmaceuticals due to its nontoxicity and versatility. When modified with methacrylate, GC forms a photocrosslinking hydrogel, glycol chitosan methacrylate (GCMA), which is highly biocompatible and hydrophilic, making it suitable for drug delivery and tissue engineering applications. However, studies on its fundamental properties are limited.

Evaluation of Brain Stiffness in Patients Undergoing Carotid Angioplasty and Stenting Using Magnetic Resonance Elastography.

Background: Percutaneous transluminal angioplasty and stenting (PTAS) in patients with carotid stenosis may have potential effects on brain parenchyma. However, current studies on parenchymal changes are scarce due to the need for advanced imaging modalities. Consequently, the alterations in brain parenchyma following PTAS remain an unsolved issue.

Advanced Patient Selection for Percutaneous Transluminal Angioplasty and Stenting for Severe Symptomatic Stenosis of the Subclavian Artery: Quantitative Evaluation with DHI and SF-36 Questionnaires.

Objective: This study was designed to quantitatively evaluate the clinical effectiveness of percutaneous transluminal angioplasty and stenting (PTAS) in patients with severe symptomatic stenosis of the subclavian artery (SSS/SA) via the Dizziness Handicap Inventory (DHI) and SF-36 questionnaires.

Methods: This was a reanalysis of a prospective, single-center study which was conducted from 2015 to 2024. The inclusion criteria were 1) patients who had significant stenosis (≧70%) of a single SA, 2) medically refractory symptoms, 3) abnormal blood flow patterns in the ipsilateral vertebral artery on dynamic sonographic images, and 4) no other possible causes of dizziness.

MRI findings for the pretreatment diagnosis of small Meckel's cave tumors: comparison of meningiomas and schwannomas.

Background: Both meningiomas and schwannomas are the most common Meckel's cave (MC) tumors in terms of distinct imaging features. When they are small, they may present with similar imaging characteristics that make their diagnosis difficult. The aim of this study was to diagnose small meningiomas and schwannomas of the MC on the basis of their clinical and MRI findings.

Peritherapeutic intra-arterial flow changes predict long-term stent patency in patients with severe intracranial artery stenosis receiving PTAS.

Background And Purpose: The quantitative intra-arterial flow dynamics following percutaneous transluminal angioplasty and stenting (PTAS) for severe intracranial artery stenosis have never been investigated. We aimed to evaluate peritherapeutic intracranial artery flow dynamics following PTAS with quantitative magnetic resonance angiography (qMRA) to predict long-term stent patency.

Design: This is a prospective, single-center study.

Bioassay and Pharmacokinetic Characteristics of Xanthium strumarium Plant Extract as Possible Acaricidal Agent.

Background: Effective management strategies against tick infestations are necessary because tickborne diseases represent serious hazards to the health of humans and animals worldwide. The aim of this study was to examine the larvicidal and ovicidal properties of extract against a notorious tick species, Methodology: The maceration method was used to prepare the ethanolic extract of . The extract was then used in an adult immersion test (AIT) and larval packet test (LPT) to asses the plant's toxicity.

Reversible Carrier Modulation in InP Nanolasers by Ionic Liquid Gating with Low Energy Consumption.

Nanoscale light sources are demanded vigorously due to rapid development in photonic integrated circuits (PICs). III-V semiconductor nanowire (NW) lasers have manifested themselves as indispensable components in this field, associated with their extremely compact footprint and ultra-high optical gain within the 1D cavity. In this study, the carrier concentrations of indium phosphide (InP) NWs are actively controlled to modify their emissive properties at room temperature.

Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.

Background: Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insufficient phenotyping. The phasic and spatial dynamics across migraine subtypes remains poorly characterized. This study aimed to determine spatiotemporal dynamics of gray matter (GM) perfusion in migraine.

Endovascular management of intracranial carotid blowout syndrome in patients with head and neck cancer.

Background: Carotid blowout syndrome is a serious complication of head and neck cancer (HNC) that may involve the intracranial or extracranial internal carotid artery (ICA). Although parent artery occlusion (PAO) is the major endovascular treatment for intracranial carotid blowout syndrome (iCBS), the efficacy of using a balloon-expandable coronary stent-graft (BES) remains unclear.

Methods: This was a quasi-randomized trial, prospective study that included patients with iCBS treated by BES or PAO between 2018 and 2024.

Early Improvement in Interstitial Fluid Flow in Patients With Severe Carotid Stenosis After Angioplasty and Stenting.

Background And Purpose: This study aimed to investigate early changes in interstitial fluid (ISF) flow in patients with severe carotid stenosis after carotid angioplasty and stenting (CAS).

Methods: We prospectively recruited participants with carotid stenosis ≥80% undergoing CAS at our institute between October 2019 and March 2023. Magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), and the Mini-Mental State Examination (MMSE) were performed 3 days before CAS.

Quantitative diagnosis of carotid blowout syndrome with CT perfusion: Carotid blowout syndrome CTP quantitative diagnosis.

Background And Purpose: Carotid blowout syndrome (CBS) is a potentially fatal disease. The CBS diagnosis mainly relies on subjective observations and the quantitative diagnotic method was not well established. This study aimed to diagnose CBS severity by computed tomography perfusion (CTP) parameters with different region-of-interest (ROI) models.

African swine fever; insights into genomic aspects, reservoirs and transmission patterns of virus.

African swine fever is a hemorrhagic disease of pigs with high mortality rates. Since its first characterization in 1921, there has been sufficient information about African swine fever virus (ASFV) and related diseases. The virus has been found and maintained in the sylvatic cycle involving ticks and domestic and wild boars in affected regions.

Aphrodisiac Principles and other Constituents from the Roots of and .

Bioassay-guided fractionation of and root extracts afforded six compounds. Among these, two bioactive compounds ginsenoside Re () and (20)-ginsenoside Rg2 () exhibiting significant relaxation in rabbit corpus cavernosum with EC values of 95.1 and 114.

Dynamic changes in glymphatic function in reversible cerebral vasoconstriction syndrome.

Background: The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and the role of glymphatics in RCVS pathophysiology has not been evaluated. We aimed to investigate RCVS glymphatic dynamics and its clinical correlates.

Methods: We prospectively evaluated the glymphatic function in RCVS patients, with RCVS subjects and healthy controls (HCs) recruited between August 2020 and November 2023, by calculating diffusion-tensor imaging along the perivascular space (DTI-ALPS) index under a 3-T MRI.

Nε-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFκB axis in Osteosarcoma.

Osteosarcoma is an extremely aggressive bone cancer with poor prognosis. Nε-(1-Carboxymethyl)-L-lysine (CML), an advanced glycation end product (AGE), can link to cancer progression, tumorigenesis and metastasis, although the underlying mechanism remains unclear. The role of CML in osteosarcoma progression is still unclear.

Endovascular Management of Post-Irradiated Carotid Blowout Syndrome in Patients with Lower Neck Cancers.

Objective: Lower neck cancers (LNCs) include specific tumour types and have some different vascular supply or collaterals from other head and neck cancers. This prospective study evaluated the outcome of endovascular management of post-irradiated carotid blowout syndrome (PCBS) in patients with LNC by comparing reconstructive management (RE) and deconstructive management (DE).

Methods: This was a single centre, prospective cohort study.

Impaired cerebral interstitial fluid dynamics in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy, caused by cysteine-altering variants in , is the most prevalent inherited cerebral small vessel disease. Impaired cerebral interstitial fluid dynamics has been proposed as one of the potential culprits of neurodegeneration and may play a critical role in the initiation and progression of cerebral small vessel disease. In the present study, we aimed to explore the cerebral interstitial fluid dynamics in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy and to evaluate its association with clinical features, imaging biomarkers and disease severity of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy.

Association between impaired dynamic cerebral autoregulation and BBB disruption in reversible cerebral vasoconstriction syndrome.

Background: Half of the sufferers of reversible cerebral vasoconstriction syndrome (RCVS) exhibit imaging-proven blood-brain barrier disruption. The pathogenesis of blood-brain barrier disruption in RCVS remains unclear and mechanism-specific intervention is lacking. We speculated that cerebrovascular dysregulation might be associated with blood-brain barrier disruption in RCVS.

Impaired Glymphatic and Meningeal Lymphatic Functions in Patients with Chronic Migraine.

Objective: This study was undertaken to investigate migraine glymphatic and meningeal lymphatic vessel (mLV) functions.

Methods: Migraine patients and healthy controls (HCs) were prospectively recruited between 2020 and 2023. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index for glymphatics and dynamic contrast-enhanced magnetic resonance imaging parameters (time to peak [TTP]/enhancement integral [EI]/mean time to enhance [MTE]) for para-superior sagittal (paraSSS)-mLV or paratransverse sinus (paraTS)-mLV in episodic migraine (EM), chronic migraine (CM), and CM with and without medication-overuse headache (MOH) were analyzed.