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Pneumatic artificial muscles (PAMs) have a wide range of robotics applications, especially in soft robots, for their ability to generate linear force and displacement with the soft, lightweight, compact, and safe characteristics as well as high power densities. However, the compressibility of the air causes a spring-like behavior of PAMs, resulting in several common issues of limited stroke, load-dependent stroke lengths, difficulty in maintaining their length against disturbance, and necessity of accurate pressure control system. To address these issues, this study borrows inspiration from a biological soft linear actuator, a muscle, and proposes a ratchet-integrated pneumatic actuator (RIPA). Utilizing two pawls integrated at both ends of a McKibben muscle and a flexible rack inserted in the middle of the muscle, the RIPA achieves a large stroke length by accumulating displacements from multiple small strokes of the McKibben muscle by repeating the cycle of pressurization and depressurization. This cycle mimics the cross-bridge model of a sarcomere, a basic unit of a skeletal muscle, in which a muscle accumulates nanoscale strokes of myosin head motors to generate large strokes. The synergy between a PAM and the inspiration from a sarcomere enabled a large-stroke soft linear actuator that can generate independent strokes from loads. The proposed actuator is not only capable of maintaining its length against unexpected mechanical disturbances but also controllable with a relatively simple system. In this paper, we describe the design of the RIPA and provide analytical models to predict the stroke length and the period per cycle for actuation. We also present experimental results for characterization and comparison with model predictions.
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http://dx.doi.org/10.1088/1748-3190/ab7762 | DOI Listing |
Microb Pathog
September 2025
College of Life Sciences and Technology, Beijing University of Chemical Technology, Beijing 100029 China; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
The antibiotic-resistant Enterococcus faecium (E. faecium) is a significant health issue requiring alternative therapies. Phages could be an alternative to antibiotics and have promising activity in both in vitro and in vivo experiments.
View Article and Find Full Text PDFACS Sens
September 2025
The State Key Laboratory of Mechanical System and Vibration, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Tactile sensing arrays play a crucial role in human-machine interaction, robotics, and artificial intelligence by enabling the perception of physical stimuli on robotic surfaces or human skin. However, skin-attachable sensor arrays still suffer from strain interference and signal crosstalk under stretching or bending, particularly on curved or deformable surfaces. Here, we present a stretchable tactile array that is both strain-insensitive and crosstalk-suppressed, achieved via a hierarchically segmented design that mitigates lateral and vertical deformations synergistically.
View Article and Find Full Text PDFCancer
September 2025
Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Ontario, Canada.
Background: The objective of this study was to evaluate whether dosimetric sparing of uninvolved normal tissues, including skin/subcutaneous flaps, affects acute and late toxicities in preoperative image-guided intensity-modulated radiation therapy (IG-IMRT) for lower extremity soft tissue sarcomas (LE-STS).
Methods: Patients with LE-STS from a phase 2 preoperative IG-IMRT trial (flap-sparing-IMRT, 2005-2009) and a prospectively maintained institutional database (standard-IMRT, 2005-2020) were propensity matched by age, sex, tumor size, grade, location, wound closure, and interval from IG-IMRT to surgery; all received 50 Gy in 25 fractions preoperatively. The primary outcome was major wound complication (MWC).
Stat Med
September 2025
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.
Studying the association between mixtures of environmental exposures and health outcomes can be challenging due to issues such as correlation among the exposures and non-linearities or interactions in the exposure-response function. For this reason, one common strategy is to fit flexible nonparametric models to capture the true exposure-response surface. However, once such a model is fit, further decisions are required when it comes to summarizing the marginal and joint effects of the mixture on the outcome.
View Article and Find Full Text PDFChaos
September 2025
Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku 113-8656, Tokyo, Japan.
The output-side behaviors of typical digital computing systems, such as simulated neural networks, are generally unaffected by the act of observation; however, this is not the case for the burgeoning field of physical reservoir computers (PRCs). Observer dynamics can limit or modify the natural state information of a PRC in many ways, and among the most common is the conversion from analog to digital data needed for calculations. Here, to aid in the development of novel PRCs, we investigate the effects of bounded, quantized observations on systems' natural computational abilities.
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