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http://dx.doi.org/10.1212/CPJ.0000000000000692 | DOI Listing |
BMJ Case Rep
August 2025
Institute of Neurology, Molecular Neuroscience, Queen Square, London, WC1N 3BG, UK.
Urinary frequency, urgency and nocturia are common complaints in Parkinson's disease (PD). The hypothesis most widely proposed to explain neurogenic bladder symptoms in PD is that cell loss in the substantia nigra may cause detrusor hyperactivity due to a loss in the D1 receptor-mediated tonic inhibition of the micturition reflex, although other causes including anti-parkinsonian medication cortical effects have been considered.1 We present the clinical and pathological findings of a patient with parkinsonism who presented with prominent dysautonomia and a poor response to dopaminergic medications and was considered to have possible multiple system atrophy parkinsonism (MSA-P).
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
August 2025
Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Purpose: Substance P (SP) is important in the physiological and pathophysiological functions of the bladder, including bladder sensory disorders like interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB). However, the impact of SP on sensory function is not fully understood. The aim of this study was to determine the effects of SP on bladder function in relation to capsaicin, specifically on bladder afferent nerve activity.
View Article and Find Full Text PDFNeurourol Urodyn
July 2025
Department of Neurological Surgery, University of Washington, Seattle, Washington, USA.
Unlabelled: Despite modern bladder management methods, lower and upper urinary tract complications still contribute significantly to morbidity and diminished quality of life in persons with spinal cord injuries (SCI). Neurogenic overactive bladders often develop after SCI and this can result in loss of compliance, with concomitant urinary tract complications. Currently, there is no treatment available to prevent the development of neurogenic bladder.
View Article and Find Full Text PDFNitric Oxide
October 2025
Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, 783-8505, Japan.
Brain nitric oxide (NO), produced by NO synthase (NOS), exerts both facilitatory and inhibitory effects on micturition. A functional relationship between NO and nicotinic acetylcholine receptors (nAChRs) has been indicated, and we previously reported that stimulation of brain α7 nAChR suppresses the micturition reflex in rats. In this study, we investigated which brain NOS isozyme is involved in micturition regulation and how NO influences α7 nAChR-mediated suppression.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
September 2025
Department of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
This study aimed to investigate the efficacy of different electrical waveforms in suppressing bladder overactivity during acute tibial nerve stimulation (TNS) in cats. Cystometric measurements were performed during intravesical infusion of either acetic acid (AA) or normal saline (NS) control solution. Bipolar hook electrodes were implanted on the left tibial nerve for stimulation.
View Article and Find Full Text PDF