Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have been employed in several biomedical applications where they facilitate both diagnostic and therapeutic aims. Although the potential benefits of SPIONs with different surface chemistry and conjugated targeting ligands/proteins are considerable, complicated interactions between these nanoparticles (NPs) and cells leading to toxic impacts could limit their clinical applications. Hence, elevation of our knowledge regarding the SPION-related toxicity is necessary. Here, the present review article will consider current studies and compare the potential toxic effect of SPIONs with or without identical surface chemistries on different cell lines. It centers on cellular and molecular mechanisms underlying toxicity of SPIONs. Likewise, emphasis is being dedicated for toxicity of SPIONs in various cell lines, and animal models, .
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/21691401.2019.1709855 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Beta-cyclodextrin decorated hyaluronic acid-coated SPIONs for improved delivery of temozolomide.
Int J Pharm
September 2025
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland. Electronic address:
Although temozolomide (TMZ) is routinely used in the treatment of glioblastoma multiforme, it is characterized by low stability, a short half-life, and serious side effects. Therefore, a new system for the effective, targeted delivery of TMZ based on superparamagnetic iron oxide nanoparticles (SPION) has been proposed. The nanoparticles were coated with hyaluronic acid, which acted as a stabilizing shell and targeting unit capable of effectively interacting with glioblastoma cells via the CD44 receptor.
View Article and Find Full Text PDFNovel Perineural Pathways and The Dynamics of Simian Immunodeficiency Virus-Infected Macrophage Trafficking Out of the Central Nervous System.
Am J Pathol
September 2025
Morrissey College of Arts and Sciences, Biology Department, Boston College, Chestnut Hill, MA, USA. Electronic address:
A challenge to eradicate HIV is the CNS reservoir and unknown mechanisms-pathways by which infected macrophages can exit. We used intracisternal (i.c.
View Article and Find Full Text PDFMagnetomechanical Detachment of Bacterial Biofilms Using Anisotropic Magnetic Iron Oxide Nanochains.
ACS Appl Bio Mater
September 2025
Department of Biotechnology, Jožef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia.
Bacterial biofilms attach to various surfaces and represent an important clinical and public health problem, as they are highly recalcitrant and are often associated with chronic, nonhealing diseases and healthcare-associated infections. Antibacterial agents are often not sufficient for their elimination and have to be combined with mechanical removal. Mechanical forces can be generated by actuating nonspherical (anisotropic) magnetically responsive nanoparticles in a rotating magnetic field.
View Article and Find Full Text PDFNanoparticles for Polycystic Ovary Syndrome (PCOS) Therapy: Exosomes and Synthetic Nanoparticles, Challenges and Opportunities.
Cell Biochem Funct
September 2025
Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Polycystic ovary syndrome (PCOS), the most common endocrine syndrome in females, remains a human health problem worldwide. Nano-based drug delivery system has emerged as a novel therapy against PCOS. Recent developments in nanotechnology have led to the innovation of synthetic and natural-based nanoparticles (NPs) that deliver therapeutic agents to PCOS.
View Article and Find Full Text PDFEngineered iron oxide nanoplatforms: reprogramming immunosuppressive niches for precision cancer theranostics.
Mol Cancer
September 2025
Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155 Nanjingbei Street, Heping District, Shenyang, 110001, Liaoning, China.
Iron oxide nanoparticles (IONPs) have transitioned from conventional magnetic resonance imaging (MRI) contrast agents into structurally programmable combined imaging/treatment tools, leveraging their superparamagnetism, catalytic activity, and surface engineering versatility to achieve spatiotemporal control over drug delivery and immune modulation. Advances in nanofabrication now yield size-optimized aggregates with enhanced tumor accumulation through the enhanced permeability and retention (EPR) effect, while clinically approved formulations like ferumoxytol demonstrate intrinsic immunomodulatory functionality, positioning IONPs as pivotal tools for precision oncology. Conversely, cancer immunotherapy remains limited by the immunosuppressive tumor microenvironment (TME), where cellular suppression via M2-polarized macrophages and regulatory T cells (Tregs) synergizes with physical exclusion from dense extracellular matrices and metabolic sabotage through lactate-driven acidosis.
View Article and Find Full Text PDF