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The nervous and immune systems communicate with one another and jointly influence functional responses. To highlight the many advances on this hot topic, Brain, Behavior, and Immunity conceptualized a Special Issue entitled "Dialing in the Dialogue Between Inflammation and the Brain." Recent advances and exciting developments in understanding communication pathways between the brain and the immune system during both physiological and pathological insults are highlighted.
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http://dx.doi.org/10.1016/j.bbi.2020.01.022 | DOI Listing |
Expert Opin Ther Targets
August 2025
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Introduction: Hypertension is a major health problem worldwide, yet fewer than half of patients maintain adequate blood-pressure control, pointing to hidden pathogenic drivers and therapeutic gaps. Normal pressure regulation depends on seamless cross-talk among the kidney, vasculature, brain, and gut; once this dialogue falters, low-grade, T cell-centered inflammation sustains disease.
Areas Covered: In the kidney, CD8 T cells bearing the purinergic receptor P2X7sense extracellular ATP and hypertonicity, upregulate renal sodium transporters, and lock in salt.
Front Syst Biol
December 2024
Precision Medicine and Computational Biology, Sanofi US, Cambridge, MA, United States.
Immune-mediated diseases are characterized by aberrant immune responses, posing significant challenges to global health. In both inflammatory and autoimmune diseases, dysregulated immune reactions mediated by tissue-residing immune and non-immune cells precipitate chronic inflammation and tissue damage that is amplified by peripheral immune cell extravasation into the tissue. Chemokine receptors are pivotal in orchestrating immune cell migration, yet deciphering the signaling code across cell types, diseases and tissues remains an open challenge.
View Article and Find Full Text PDFLupus Sci Med
July 2025
Division of Rheumatology, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
J Orthop Surg Res
July 2025
Department of Blood Transfusion, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
Degenerative orthopedic illnesses, such as osteoporosis (OP) and intervertebral disc degeneration (IVDD), are common in the elderly and are defined by loss of bone mass and degradation of the intervertebral disc matrix, respectively. These conditions cause persistent pain and disability. Although more research has been done on the two diseases' distinct causes, epidemiology indicates that their co-morbidity incidence has dramatically grown, pointing to a synergistic pathogenic network.
View Article and Find Full Text PDFJ Cell Mol Med
July 2025
Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
To explore the innate immune response in the occurrence and development of APAP-induced drug-induced liver injury and the biological effect caused by the interaction between immune cells through real-time, in vivo analysis. We used conventional molecular biology technology and multi-photon confocal live imaging to explore the effect of the interactive dialogue between iNKT and Kupffer cells on neutrophil recruitment in the occurrence and development of APAP-induced liver injury. iNKT cell deficient mice were more prone to liver injury induced by excessive APAP, and the degree of liver injury was more severe.
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