Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
When investigating the body's mechanisms for regulating cerebral blood flow, a relative measurement of microcirculatory blood flow can be obtained using laser Doppler flowmetry (LDF). This paper demonstrates a closed skull preparation that allows cerebral blood flow to be assessed without penetrating the skull or installing a chamber or cerebral window. To evaluate autoregulatory mechanisms, a model of controlled blood pressure reduction via graded hemorrhage can be utilized while simultaneously employing LDF. This enables the real time tracking of the relative changes in the blood flow in response to reductions in arterial blood pressure produced by the withdrawal of circulating blood volume. This paradigm is a valuable approach to study cerebral blood flow autoregulation during reductions in arterial blood pressure and, with minor modifications in the protocol, is also valuable as an experimental model of hemorrhagic shock. In addition to evaluating autoregulatory responses, LDF can be used to monitor the cortical blood flow when investigating metabolic, myogenic, endothelial, humoral, or neural mechanisms that regulate cerebral blood flow and the impact of various experimental interventions and pathological conditions on cerebral blood flow.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3791/60540 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combinatorial targeting of PI3K/AKT pathway with BKM120 increases cisplatin sensitivity and apoptotic response in A549 lung cancer cells.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Despite significant advancements in the treatment of non-small cell lung cancer (NSCLC) using conventional therapeutic methods, drug resistance remains a major factor contributing to disease recurrence. In this study, we aimed to explore the potential benefits of combining PI3K inhibition with Cisplatin in the context of NSCLC-derived A549 cells. Human non-small cell lung cancer A549 cells were cultured and treated with BKM120, cisplatin, or their combination.
View Article and Find Full Text PDFCerebral autoregulation in orthostatic hypotension and falls among older adults: a community-based exploratory study.
Clin Auton Res
September 2025
Faculty of Medicine, Department of Medicine, Ageing and Age-Associated Disorders Research Group, Division of Geriatric Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Background: Orthostatic hypotension (OH) is prevalent in older adults and is often associated with falls. However, the presence or absence of symptoms in OH may be mediated by cerebral autoregulation, which helps maintain cerebral perfusion during blood pressure fluctuations.
Methods: We recruited 40 older adults (aged ≥ 55 years) from the Malaysian Elders Longitudinal Research (MELoR) cohort.
Isolated spinal aneurysms with spontaneous regression.
Neurosurg Rev
September 2025
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Purpose: To share our clinical experience with conservative management of isolated spinal arterial aneurysms (ISAs) and to identify clinical scenarios where conservative management may be appropriate, in the context of a literature review.
Methods: We performed a retrospective review of spinal angiograms from two German neuroradiology centers and conducted a systematic literature review of reported ISA cases. We analyzed demographics, clinical presentation, imaging findings, treatments, and outcomes.
[Features of peripheral blood lymphocyte subpopulation profile in children with newly diagnosed untreated retinoblastoma].
Vestn Oftalmol
September 2025
Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.
Unlabelled: Retinoblastoma is a malignant retinal tumor characterized by an aggressive clinical course, with frequent recurrences and the emergence of new foci even during chemotherapy.
Objective: This study investigated the subpopulation composition of peripheral blood lymphocytes in children with newly diagnosed untreated retinoblastoma.
Material And Methods: A total of 24 children (48 eyes) were examined between December 20, 2023, and September 1, 2024; retinoblastoma was diagnosed in 28 eyes.
Computational Fluid Dynamics of the Flow of the Deformable Toroidal Embolic Agents Within Straight and Stenotic Pipes by Full Eulerian FSI Method.
Int J Numer Method Biomed Eng
September 2025
Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
The effect of shape and size of embolic agents on embolization phenomena has been discussed clinically for transcatheter arterial chemoembolization (TACE). We numerically discussed the unique embolization behavior of new deformable toroidal microparticles in blood vessels by computational fluid dynamics simulations. We employed an Eulerian-Eulerian (full Eulerian) fluid-structure interaction (FSI) method to analyze the flow and deformation behaviors of a deformable torus in a cylindrical pipe.
View Article and Find Full Text PDF