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Protective arm reactions were evoked in 14 younger adults to determine the effect of fall height on protective arm reaction biomechanics. Participants were supported in a forward-leaning position on top of an inverted pendulum that isolated arm reaction by preventing any fall arresting contribution that may come from the ankle, knees, or hip. At an unpredictable time, the pendulum was released requiring participants to rapidly orient their arms to protect the head and body. Vertical ground reaction force (vGRF), arm kinematics, and electromyographic (EMG) measures of the biceps and triceps were compared at four initial lean angles. The time following perturbation onset and prior to impact consisted of two phases: rapid extension of the elbows and co-activation of the biceps and triceps in preparation for impact. The rapid orientation phase was modulated with fall height while the co-activation of the biceps and triceps in preparation for landing was minimally affected. Larger lean angles resulted in increased vGRF, increased elbow extension at impact, decreased elbow angular extension velocity at impact, and increased neck velocity at impact while hand velocity at impact was not significantly affected. The neuromuscular control strategy appears to optimize elbow extension angle/angular velocity prior to co-activation of the biceps and triceps that occurs about 100 ms prior to impact. Future work should investigate how the neuromuscular control strategy handles delayed deployment of protective arm reactions.
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http://dx.doi.org/10.1016/j.jbiomech.2019.109569 | DOI Listing |
Int Arch Occup Environ Health
September 2025
Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy.
Purpose: To investigate the role of personal risk factors in the occurrence of the vascular, neurological and fibroproliferative disorders of the hand-arm vibration syndrome (HAVS) in workers groups exposed to hand-transmitted vibration (HTV).
Methods: HAVS prevalence and incidence data were pooled across a series of cross-sectional studies (total sample: 1272 HTV workers, 579 controls) and prospective cohort studies (total sample: 377 HTV workers, 138 controls) conducted in Central and North-Eastern Italy. The pooled studies included detailed individual-level information about HTV exposure, personal risk factors, medical comorbidities and HAVS disorders.
PLoS Negl Trop Dis
September 2025
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Background: The Maltalep trial in Bangladesh assessed whether single-dose rifampicin (SDR) given 8-12 weeks after bacillus Calmette-Guérin (BCG) vaccination was able to prevent excess leprosy cases due to BCG in contacts of newly diagnosed leprosy patients. After previous publication of the two years follow-up results of the trial, we now review the results after five years. Furthermore, to better understand the long-term protective effects of BCG against leprosy, we conduct post-hoc in-depth secondary statistical analyses based on the prospective interventional (randomized) Maltalep trial and a non-interventional (non-randomized) cohort study that was conducted simultaneously in the same project area.
View Article and Find Full Text PDFbioRxiv
August 2025
Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.
Vulvovaginal candidiasis (VVC), caused by the commensal pathobiont affects >75% of women, marring quality of life and incurring significant health costs. Estrogen (E2) activity is tightly linked to VVC susceptibility, and preclinical models employ E2 to establish vaginal colonization. Unlike most forms of candidiasis, VVC is not considered to be a condition of immune compromise.
View Article and Find Full Text PDFObjective: Wound healing is a complex process involving haemostasis, inflammation, proliferation and remodelling. Dysregulation in any phase impairs healing. Hyaluronic acid (HA) and amino acids are essential in promoting tissue repair.
View Article and Find Full Text PDFJ Appl Clin Med Phys
September 2025
Department of Radiology, University of Kentucky, Lexington, Kentucky, USA.
Background: Digital dynamic radiography (DDR), integrated into Konica Minolta's portable mKDR system, provides dynamic imaging for pulmonary, orthopedic, and interventional applications. While DDR is not classified as fluoroscopy, its use of pulsed x-rays for cine-like image sequences raises concerns about radiation exposure and shielding, particularly given the absence of a primary beam stop, high output capabilities, and increasing clinical adoption.
Purpose: To characterize the primary and scatter radiation output of a DDR system and compare it against commonly used mobile C-arm fluoroscopy units, and to evaluate shielding requirements and potential occupational exposure risks associated with DDR use.