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Particle accelerators represent an indispensable tool in science and industry. However, the size and cost of conventional radio-frequency accelerators limit the utility and reach of this technology. Dielectric laser accelerators (DLAs) provide a compact and cost-effective solution to this problem by driving accelerator nanostructures with visible or near-infrared pulsed lasers, resulting in a 10 reduction of scale. Current implementations of DLAs rely on free-space lasers directly incident on the accelerating structures, limiting the scalability and integrability of this technology. We present an experimental demonstration of a waveguide-integrated DLA that was designed using a photonic inverse-design approach. By comparing the measured electron energy spectra with particle-tracking simulations, we infer a maximum energy gain of 0.915 kilo-electron volts over 30 micrometers, corresponding to an acceleration gradient of 30.5 mega-electron volts per meter. On-chip acceleration provides the possibility for a completely integrated mega-electron volt-scale DLA.
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http://dx.doi.org/10.1126/science.aay5734 | DOI Listing |
Nano Lett
September 2025
Department of Physics, The University of Tokyo, Hongo, Tokyo 113-0033, Japan.
On-chip terahertz (THz) spectroscopy has attracted growing attention because of its capability of measuring samples far smaller than the Rayleigh diffraction limit. The technique also allows the investigation of nonlinear responses of materials, which is indispensable for the development of ultrafast devices operating with a THz bandwidth. Here, we report the development of an on-chip THz-pump THz-probe spectroscopy technique that enables the study of ultrafast electrical-pulse-induced nonequilibrium phenomena.
View Article and Find Full Text PDFMicrosyst Nanoeng
September 2025
Center for Terahertz Waves, College of Precision Instrument and Optoelectronics Engineering, and the Key Laboratory of Optoelectronics Information and Technology (Ministry of Education), Tianjin University, Tianjin, 300072, China.
Terahertz communication systems demand versatile devices capable of simultaneously controlling propagating waves and surface plasmon polaritons (SPPs) in far-field (FF) and near-field (NF) channels, yet existing solutions are constrained by volatile operation, single-function limitations, and the inability to integrate NF and FF functionalities. Here, we present a nonvolatile reconfigurable terahertz metasurface platform leveraging the phase-change material GeSbTe(GST) to achieve on-demand dual-channel modulation-a first in the terahertz regime. By exploiting the stark conductivity contrast of GST between amorphous and crystalline states, our design enables energy-efficient switching between NF-SPP manipulation and FF-wavefront engineering without requiring continuous power input.
View Article and Find Full Text PDFAdv Drug Deliv Rev
September 2025
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States; Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States. Electronic address:
The human microbiome plays a critical role in health and disease. Disruptions in microbiota composition or function have been implicated not only as markers but also as drivers of diverse pathologies, creating opportunities for targeted microbiome interventions. Advancing these therapies requires experimental models that can unravel the complex, bidirectional interactions between human tissue and microbial communities.
View Article and Find Full Text PDFCrit Rev Anal Chem
September 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, India.
The miniaturization of separation platforms marks a transformative shift in analytical science, merging microfabrication, automation, and intelligent data integration to meet rising demands for portability, sustainability, and precision. This review critically synthesizes recent technological advances reshaping the field-from microinjection and preconcentration modules to compact, high-sensitivity detection systems including ultraviolet-visible (UV/Vis), fluorescence (FL), electrochemical detection (ECD), and mass spectrometry (MS). The integration of microcontrollers, AI-enhanced calibration routines, and IoT-enabled feedback loops has led to the rise of self-regulating analytical devices capable of real-time decision-making and autonomous operation.
View Article and Find Full Text PDFLab Chip
September 2025
State Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, Shanghai 200240, China.
Enzymatic deoxyribonucleic acid (DNA) synthesis (EDS) is an environmentally friendly approach capable of generating longer and more complex sequences than chemical synthesis, making it a promising next-generation technology for high-throughput single-stranded DNA production. However, precise sequence control at high throughput remains a key challenge. Here, we present a novel electronically controlled deprotection chemistry (ECDC) integrated with a hydrogel-primer modification system on-chip for efficient multiplexed EDS.
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