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http://dx.doi.org/10.1093/ajhp/zxz280 | DOI Listing |
J Am Soc Echocardiogr
September 2025
From the Department of Cardiovascular Medicine, Mayo Clinic Rochester, MN 55905.
Background: Pulmonary hypertension is associated with cardiovascular events, but when assessed at rest, it has limited sensitivity. Pulmonary vascular reserve can be assessed noninvasively using exercise echocardiography, but this has not been studied in adults with coarctation of aorta (COA). We hypothesized that adults with COA had worse pulmonary vascular reserve compared to controls, and that impaired pulmonary vascular reserve was associated with clinical indices of disease severity independent right ventricular (RV) indices at rest.
View Article and Find Full Text PDFReprod Biomed Online
May 2025
Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, University Hospital of Lausanne, Lausanne, Switzerland; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Electronic address:
Research Question: What is the composition of bacterial communities at various genital sites and are there potential interactions between partners' microbiota?
Design: This observational study involved metagenomic analyses of samples collected from male and female partners of couples undergoing fertility treatment. Samples included vaginal and penile swabs, as well as follicular fluid and semen, which were analysed using next-generation sequencing.
Results: The bacterial community profiles of different genital tract niches were distinct, niche-specific compositions, with female samples predominantly featuring Lactobacillus species and male samples displaying greater microbial diversity, including genital-specific and skin-associated taxa.
Cell Metab
August 2025
Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA. Electronic address:
Diet and obesity contribute to insulin resistance and type 2 diabetes, in part via the gut microbiome. To explore the role of gut-derived metabolites in this process, we assessed portal/peripheral blood metabolites in mice with different risks of obesity/diabetes, challenged with a high-fat diet (HFD) + antibiotics. In diabetes/obesity-prone C57BL/6J mice, 111 metabolites were portally enriched and 74 were peripherally enriched, many of which differed in metabolic-syndrome-resistant 129S1/129S6 mice.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
September 2025
Technical University of Denmark, Department of Health Technology Ultrasound and Biomechanics, Ørsteds Plads, 349, 2800, Kgs. Lyngby, Denmark. Electronic address:
Background: Shield-triggered autoinjectors (AIs) aim to reduce needle phobia and accidental needlestick injuries and improve usability. However, they may cause deeper injections due to tissue compression. This study investigates the mechanical response of AI application into abdominal tissue in-vivo.
View Article and Find Full Text PDFDNA Repair (Amst)
August 2025
Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiotherapy, Erasmus MC Cancer Institute, Erasmus University Med
DNA crosslink-inducing drugs are widely used in clinical settings for treatment of solid tumors. Double strand breaks (DSBs) that arise during interstrand crosslink (ICL) repair are crucial determinants of the therapeutic response, as they lead to cell death if not repaired. DSBs can be repaired through non-homologous end joining (NHEJ), theta-mediated end joining (TMEJ), and homologous recombination (HR).
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