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Growth and physical performance scores were studied around three years of attainment of peak height velocity (PHV). We aimed to estimate the age at peak velocity, or at peak rate, in physical performance tasks, and sex-differences when aligned by biological age. A total of 131 boys and 123 girls, 8 to 14 years of age were recruited from the Cariri region of Brazil. A mixed longitudinal design was used with four overlapping age cohorts: 8, 10, 12, and 14 years, followed for three years, with measurements performed at 6 month intervals. Height, 12 min run (12mR), handgrip strength (HG), standing long jump (SLJ), and shuttle run (SR) velocities were estimated using a non-smooth mathematical procedure. Age at PHV was 13.4 ± 1.6 years in boys compared with 12.2 ± 2.3 years in girls. Maximal velocity in SLJ was attained 6 and 3 months prior to PHV in boys and girls, respectively. For HG, peaks were attained 9 months after PHV in boys and 15 months after PHV in girls. Maximal velocity in 12mR was attained 6 months before PHV in boys and at PHV in girls, whereas a peak in SR occurred 12 months after PHV in both sexes. In conclusion, dynamic changes in physical performance relative to PHV appear similar in both sexes, although sex differences were evident in some motor tests.
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http://dx.doi.org/10.3390/ijerph16245029 | DOI Listing |
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Florida Orthopaedic Institute, Gainesville, FL, 32607, USA.
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View Article and Find Full Text PDFNat Nanotechnol
September 2025
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Adoptive T-cell therapies, and particularly CAR T cells and tumour-infiltrating lymphocytes, have transformed cancer treatment by selectively targeting malignant cells. Despite their clinical success, these therapies face substantial challenges, including costly manufacturing processes and tumour-imposed barriers that limit efficacy. Advances in understanding the nanoscale mechanisms governing T-cell activation and the role of the tumour microenvironment in restricting T-cell responses have driven the development of nanotechnology-based strategies that integrate key chemical and physical cues.
View Article and Find Full Text PDFInorg Chem
September 2025
General Education Center, Qinghai Institute of Technology, Xining 810000, China.
Zirconium disilicide (ZrSi) ceramics have excellent physical and chemical properties and are employed in aerospace, energy, and chemical industries. Currently, the preparation and properties of ZrSi ceramics have been less studied. To comprehensively study the characteristics of ZrSi ceramics, in this study, dense bulk ZrSi ceramic samples are successfully prepared by the high-pressure-high-temperature (HPHT) sintering technique.
View Article and Find Full Text PDFLancet Digit Health
September 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; NIHR Biomedical Research Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
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View Article and Find Full Text PDFPhysiol Rep
September 2025
Cook Children's Health Care System - Exercise Respiratory Center, Prosper, Texas, USA.
Exercise-induced respiratory symptoms limit physical activity and sport performance in adolescents. Etiologies include exercise-induced bronchoconstriction, laryngeal obstruction, dysfunctional breathing, and in rarer cases, large airway obstruction and cardiac pathologies. Accurate diagnosis requires assessment during exercise that elicits the symptoms patients experience in the field.
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