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Self-healing is a new strategy for crack defect which is the main reason for the failure of composites. As an extrinsic self-healing system, the microvascular network system is capable of multiple healing cycles and rapid healing of large area damage. However, the embedment of micropipe network will affect the performance of matrix material. In this article, a microvascular network of self-healing material is optimized using non-dominated sorting genetic algorithm II. Two objective functions head loss and void volume fraction are considered. Finite element analysis and Hardy Cross iteration are performed to achieve the quantization of objective functions. One hundred sixty-five optimized solutions were obtained, and the void volume fraction was within the limits of [4.19%, 5.13%], whereas the head loss was within the limits of [9.63×10 m, 6.51×10 m]. According to the optimization results, the network was prepared and tested to validate the design and feasibility. The test result shows that the void volume fraction of the prepared network is 3.77%, lower than the designed value 4.43% which has a little effect on the matrix material. The network is interconnected and the healing agent can flow freely in it. The embedded network does not reduce the performance of epoxy resin. The optimization of microvascular network balances the mechanical properties and self-repairing properties of the matrix material.
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http://dx.doi.org/10.1177/0036850419883541 | DOI Listing |
Arq Gastroenterol
September 2025
Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia, São Paulo, SP, Brasil.
Background: Accurate evaluation of the invasion depth of superficial esophageal squamous cell carcinoma (SESCC) is crucial for optimal treatment. While magnifying endoscopy (ME) using the Japanese Esophageal Society (JES) classification is reported as the most accurate method to predict invasion depth, its efficacy has not been tested in the Western world. This study aims to evaluate the interobserver agreement of the JES classification for SESCC and its accuracy in estimating invasion depth in a Brazilian tertiary hospital.
View Article and Find Full Text PDFJ Infect Dis
September 2025
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA USA.
Sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the microvasculature is a major virulence determinant. While the sequestration of mature stage parasites (trophozoite and schizonts) to vascular endothelium is well established, the conditions that promote ring-stage IE sequestration is less understood. Here, we observed in ring-stage parasites that febrile exposure increased transcript levels of several exported parasite genes involved in the trafficking of the P.
View Article and Find Full Text PDFPLoS Pathog
September 2025
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Neuroinflammation within the central nervous system (CNS) is recognized as a critical pathological process in meningitic Escherichia coli (E. coli) infection, leading to severe neurodegenerative disorders and long-term sequelae. Astrocyte reactivity plays a pivotal role in driving the neuroinflammatory cascade in response to pathological stimuli from peripheral sources or other cellular components of the CNS.
View Article and Find Full Text PDFAngiogenesis
September 2025
Division of Plastic Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, 17033, USA.
Vascularization of implanted biomaterials is critical to reconstructive surgery and tissue engineering. Ultimately, the goal is to promote a rapidly perfusable hierarchical microvasculature that persists with time and can meet underlying tissue needs. We have previously shown that using a microsurgical technique, termed micropuncture (MP), in combination with porous granular hydrogel scaffolds (GHS) fabricated via interlinking hydrogel microparticles (microgels) results in a rapidly perfusable patterned microvasculature.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.