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http://dx.doi.org/10.1159/000496546 | DOI Listing |
Neurochem Res
September 2025
Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Intracerebral hemorrhage (ICH) is a common yet severe cerebrovascular disorder associated with high morbidity, disability, and mortality rates. Kaempferol (Kae), a natural flavonoid with potent antioxidant and anti-inflammatory properties, has shown promise in neuroprotection; however, its therapeutic potential in promoting neurological recovery after ICH remains unclear. In this study, we investigated the neuroprotective effects of Kae in ICH and explored its underlying mechanisms using in vitro and in vivo models.
View Article and Find Full Text PDFMed Sci Monit
September 2025
Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China.
BACKGROUND Multiple factors impact the prognosis of intracerebral hemorrhage (ICH). This study aimed to evaluate prognosis at 90 days after ICH in 561 patients using the numerical rating scale (NRS), the Braden scale, the Morse fall risk scale (MFS), and the enhanced modified early warning (MEW) scale. MATERIAL AND METHODS A retrospective study was performed among 561 patients with ICH diagnosed in our hospital.
View Article and Find Full Text PDFSci Rep
September 2025
Department of Neurosurgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Moorenstraße 5, 40225, Duesseldorf, Germany.
Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition associated with high rates of morbidity and mortality, mainly due to post-hemorrhagic complications such as cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI). Recent evidence implicates platelet activation and inflammatory mediators in the cascade of secondary injury following aSAH. Monitoring and timely treatment of post-SAH complications is critical to improve clinical outcomes.
View Article and Find Full Text PDFExp Biol Med (Maywood)
September 2025
Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
The potential of mesenchymal stromal cells (MSCs) in the treatment of hemorrhagic stroke has been demonstrated; however, their clinical efficacy remains inconsistent and further comprehensive studies on their mechanism of action are warranted. In this study, the intracerebral hemorrhage (ICH) rat model was used for intravenous infusion of adipose-derived mesenchymal stromal cells (AD-MSCs) 24 h after modeling. Histopathological techniques and single cell transcriptome sequencing techniques were used to study the mechanism of AD-MSCs promoting the repair of damaged brain tissue.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Unlabelled: Bleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis aimed to assess frequency and determinants of BTE according to their location and severity in a retrospective analysis of the German ECMO COVID-19 registry. Logistic regression was applied to identify factors influencing ICU survival as well as variables associated with risks of BTE.
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