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We propose three different methods to determine the optimal number of hidden nodes based on L regularization for a multilayer perceptron network. The first two methods, respectively, use a set of multiplier functions and multipliers for the hidden-layer nodes and implement the L regularization on those, while the third method equipped with the same multipliers uses a smoothing approximation of the L regularization. Each of these methods begins with a given number of hidden nodes, then the network is trained to obtain an optimal architecture discarding redundant hidden nodes using the multiplier functions or multipliers. A simple and generic method, namely, the matrix-based convergence proving method (MCPM), is introduced to prove the weak and strong convergence of the presented smoothing algorithms. The performance of the three pruning methods has been tested on 11 different classification datasets. The results demonstrate the efficient pruning abilities and competitive generalization by the proposed methods. The theoretical results are also validated by the results.
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http://dx.doi.org/10.1109/TCYB.2019.2950105 | DOI Listing |
NAR Genom Bioinform
September 2025
Centre for Integrative Biology and Systems Medicine (IBSE), Wadhwani School of Data Science and AI, Indian Institute of Technology (IIT) Madras, Chennai 600036, India.
Genome graphs provide a powerful reference structure for representing genetic diversity. Their structure emphasizes the polymorphic regions in a collection of genomes, enabling network-based comparisons of population-level variation. However, current tools are limited in their ability to quantify and compare structural features across large genome graphs.
View Article and Find Full Text PDFIEEE Trans Comput Biol Bioinform
September 2025
The study of the relationship between circular RNA (circRNA) and disease is crucial for understanding the mechanisms underlying disease onset. However, relying on biological experiments to explore all potential connections between circRNAs and diseases is both time-consuming and labor-intensive. While various prediction methods have been proposed, they still possess certain limitations in their ability to extract deep features.
View Article and Find Full Text PDFIEEE Trans Comput Biol Bioinform
January 2025
Gene expression profiling is used in many biological and biomedical studies. The L1000 assay is an efficient profiling method that measures the expression of a small number of "landmark" genes and predicts the expression of the remaining "target" genes. Extreme gradient boosting and deep neural networks (DNNs) have shown high accuracy in predicting target gene expression based on landmark genes.
View Article and Find Full Text PDFPLoS One
July 2025
School of Information, Liaoning University, Shenyang, Liaoning, China.
The working state of rolling bearing severely affects the performance of industrial equipment. Addressing the issue of that the difficulty of incipient weak signals feature extraction influences the rolling bearing diagnosis accuracy, an efficient bearing fault diagnostic technique, a proposition is forwarded for hybrid artificial intelligence models, which integrates Improved Harris Hawks Optimization (IHHO) into the optimization of Deep Belief Networks and Extreme Learning Machines (DBN-ELM). The process employs Maximum Second-order Cyclostationary Blind Deconvolution (CYCBD) to filter out noise from the vibration signals emitted by bearings; secondly, considering the issue with the conventional Harris Hawks Optimization (HHO) algorithm which tends to prematurely converge to local optima, the differential evolution mutation operator is introduced and the escape energy factor is improved from linear to nonlinear in IHHO; then, a double-layer network model based on DBN-ELM is proposed, to avoid the number of hidden layer nodes of DBN from human experience interference, and IHHO is used to optimize DBN structure, which is denoted as IHHO-DBN-ELM method; with the optimal structure is obtained by using a combined IHHO optimized DBN and ELM; in conclusion, the proposed IHHO-DBN-ELM approach is applied to the bearing fault detection using the Western Reserve University's bearing fault dataset.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
August 2025
ENT Department and Cervical Surgery Farhat Hached Hospital, Medicine University, Sousse, Tunisia.
Objective: Determine the rate of occult lymph node metastasis in advanced laryngeal squamous cell carcinoma and identify its predictive factors.
Methods: A retrospective study including 98 patients with laryngeal cancer classified as T3-T4 N0, who underwent bilateral lymph node dissection in sectors II, III and IV.
Result: The median age of our patients was 61.