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http://dx.doi.org/10.1093/nar/gkz1090 | DOI Listing |
Commun Chem
September 2025
Dresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technische Universität Dresden, Dresden, Germany.
Purely organic materials showing efficient and persistent emission via room temperature phosphorescence (RTP) allow the design of minimalistic yet powerful technological solutions for sensing, bioimaging, information storage, and safety applications using the photonic design principle of digital luminescence. Although several promising materials exist, a deep understanding of the underlying structure-property relationship and, thus, development of rational design strategies are widely missing. Some of the best purely organic emitters follow the donor-acceptor-donor design motif.
View Article and Find Full Text PDFNature
September 2025
Research Center for Industries of the Future, Westlake University, Hangzhou, China.
The electrolyte-electrode interface serves as the foundation for a myriad of chemical and physical processes. In battery chemistry, the formation of a well-known solid-electrolyte interphase (SEI) plays a pivotal role in ensuring the reversible operations of rechargeable lithium-ion batteries (LIBs). However, characterizing the precise chemical composition of the low crystallinity and highly sensitive SEI presents a formidable challenge.
View Article and Find Full Text PDFJ Safety Res
September 2025
China Construction Eighth Engineering Division Corp., Ltd Southwest Branch, No. 1480 Tianfu Avenue, High-tech Zone, Chengdu 610096, China.
Introduction: Decision-making failure is a critical factor influencing workers' unsafe behavior. While previous research has predominantly concentrated on rational decision-making failures, it has largely ignored the impact of irrational decision-making failures and the mechanisms through which these failures contribute to unsafe behaviors. This oversight limits our understanding of how unsafe behavior develops.
View Article and Find Full Text PDFInt J Antimicrob Agents
September 2025
Dalle Molle Institute for Artificial Intelligence IDSIA. USI/SUPSI, Via la Santa 1, CH-6962 Lugano-Viganello, Switzerland. Electronic address:
Cell-penetrating peptides (CPPs) are powerful vectors for the intracellular delivery of a diverse array of therapeutic molecules. Despite their potential, the rational design of CPPs remains a challenging task that often requires extensive experimental efforts and iterations. In this study, we introduce an innovative approach for the de novo design of CPPs, leveraging the strengths of machine learning (ML) and optimization algorithms.
View Article and Find Full Text PDFBiomaterials
September 2025
Department of Biomedical Engineering, Program in Genetic Drug Engineering, Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:
Modular lipid nanoparticles (LNPs) are a promising platform to deliver mRNA to various tissues and cells. Optimization of LNPs for hepatic and extrahepatic tissues often involves substitution of helper lipids or addition of novel lipids not found in conventional four-component LNPs. Among the lipids that comprise LNPs, the functional contributions of phospholipids (PLs) in selective organ targeting (SORT) LNPs remain poorly understood.
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