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As the focus of clinicians and government shifts from speciality-based care to system-based key performance indicators such as the National Emergency Access Target (NEAT) or the 4-h rule, integration between emergency department (ED) and inpatient clinical workflows and information systems is becoming increasingly necessary. Such system measures drive the implementation of integrated electronic medical records (ieMR) to digitally integrate these workflows. The objective of this case study was to describe the impact of digital transformation of the ED-in-patient interface (EDii) of a large tertiary hospital on process measures and clinical outcomes for patients requiring emergency admission to hospital. Data were collected from routine clinical and administrative information systems to measure process and clinical outcome measures, including ED length of stay, compliance with the 4-h rule and in-patient mortality between 28 November 2014 and 28 February 2017. The 4-h rule compliance for all patients, as well as for the EDii group (admitted to hospital excluding short stay ward), declined after digitisation. There were 55 fewer deaths in the postintervention group (15% relative reduction; P = 0.02) and a 10% relative reduction in adjusted mortality as measured by the Hospital Standardised Mortality Ratio for emergency patients (eHSMR), which did not reach statistical significance. Digital deceleration in ED performance did occur with an ieMR rollout, but worsening of key patient outcomes was not observed.
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http://dx.doi.org/10.1071/AH18176 | DOI Listing |
Clin Chem Lab Med
September 2025
Department of cardiology, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.
Objectives: To assess the imprecision and stability of the point-of-care troponin I assay in the Emergency Department and its correlation and bias to two central laboratory troponin I assays (Siemens Atellica and Abbott Alinity).
Methods: Imprecision and stability testing was performed on opportunistically selected samples using whole blood in the emergency department by non-laboratory trained personnel. Assay comparisons were undertaken on samples taken from participants of the Mersey Acute Coronary syndrome Rule Out Study.
Sci Rep
August 2025
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Hepatocellular carcinoma (HCC) is one of the life-threatening cancers in the current decade. Earlier reports suggest that protein arginine methyl transferase 5 (PRMT5) is also linked with HCC, and the symmetrically dimethylated arginine marks created by PRMT5 are read by the Staphylococcal nuclease domain-containing protein 1 (SND1), which eventually can drive HCC development. Indeed, as no inhibitors have been ascertained for SND1, we aimed to screen for new inhibitors with specificity and high affinity towards the active site of SND1.
View Article and Find Full Text PDFJ Phys Chem A
May 2025
Department of Chemistry, Stanford University, Stanford, California 94305, United States.
Several lines of evidence are presented that when ultrapure water is sprayed into air and the resulting water microdroplets are mass analyzed a peak at / 36 appears, which is identified as the water dimer cation. The water dimer cation, (HO), and the hydrated ammonium cation, NH·HO, have essentially indistinguishable mass differences in a low-resolution mass spectrum. By comparing the behavior of (HO) and NH·HO with temperature and salt concentration, we can rule out the formation of NH·HO in the spraying of ultrapure water into laboratory air.
View Article and Find Full Text PDFFood Chem
May 2025
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:
Gamma-aminobutyric acid (GABA) is a functional food ingredient for human health. This study aimed to investigate the enrichment and migration rule of GABA in rice by heating and humidifying treatment (HHT). The thin layer chromatography-ImageJ method (TLC-ImageJ) was developed for determining GABA.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
This study investigates the preparation of coamorphous systems composed entirely of active pharmaceutical ingredients (APIs), namely praziquantel, niclosamide, and mebendazole. The objective was to formulate and characterize binary and ternary coamorphous systems to evaluate their structural, thermal, and stability properties. Ten different mixtures (binary and ternary) were designed through a mixture design approach and prepared using a sustainable, one-step neat grinding process in a lab-scale vibrational mill.
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