Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A new member of , named torque teno mini virus (TTMV)-SH, was recently identified in the serum of three Hodgkin's lymphoma patients suggesting that TTMV-SH may be associated with this type of hematological malignancy. We investigated by metagenomic analysis the presence of TTMV-SH-related viruses in plasma samples ( = 323) collected from patients with various hematological malignancies (multiple myeloma (MM, = 256), non-Hodgkin's lymphoma (NHL, = 20), acute myeloid leukemia ( = 10)) and from healthy donors ( = 37). TTMV-SH-related strains were identified in 24 samples corresponding to four MM and one NHL patients. Phylogenic analysis revealed that the 24 isolates were close to the TTMV-SH strains previously identified, sharing 79.6-86.7% ORF1 nucleotide sequence identity. These results suggest that TTMV-SH-related viruses might be found in hematological diseases other than Hodgkin's lymphoma. Due to the high genetic variability within species, the association between a particular medical condition and a new genotype should be interpreted with caution.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759482 | PMC |
| http://dx.doi.org/10.3389/fmicb.2019.01898 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immune Responses and Replication of Rescued Torque Teno Virus (TTSuV1) in Mice.
Viruses
August 2025
Department of Microbiological Sciences, North Dakota State University, Fargo, ND 58102, USA.
Although Torque Teno Viruses (TTVs) were initially considered to be ubiquitous members of the mammalian virome, the finding that swine TTVs (TTSuV) can act as primary pathogens elevates the possible status of swine TTVs (TTSuVs) to an emerging swine pathogen. Since their discovery, the molecular mechanisms of TTV-host interactions remain largely unknown as robust in vitro culture systems and in vivo animal models have not been available. This study was undertaken to address some of these long-standing gaps.
View Article and Find Full Text PDFEvaluation of Mosquito Blood Meals as a Tool for Wildlife Pathogen Surveillance.
Pathogens
August 2025
Florida Medical Entomology Laboratory, University of Florida, Vero Beach, FL 32962, USA.
Mosquito blood meals provide a biological sample of host blood which can then be used in downstream applications including host-pathogen detection. We conducted DNA barcoding to identify the host species of blood meals from 4557 blood engorged mosquitoes collected in south central Florida, USA. We identified 314 blood meals from invasive wild pigs, 219 wild turkey blood meals, and 1046 white-tailed deer blood meals.
View Article and Find Full Text PDFClinical Significance of Respiratory Torque Teno Virus in Immunocompromised Patients with Acute Respiratory Failure.
Clin Microbiol Infect
August 2025
Service de Virologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris, F-75010 Paris, France; Université Paris Cité, Inserm U976, Insight team, F-75010 Paris, France. Electronic address:
Objective: Among immunocompromised patients with acute respiratory failure, identification of those at higher risk for opportunistic infections is crucial to optimize management. The Torque teno virus (TTV) DNA burden in the blood has been identified as a surrogate marker of functional immunity in solid organ transplant recipients. This study investigates the clinical relevance of TTV DNA in nasopharyngeal swabs of immunocompromised patients with acute respiratory failure (ARF).
View Article and Find Full Text PDFVirus in infectious uveitis: bibliometric analysis and a clinical study.
Front Microbiol
August 2025
Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Introduction: In recent years, advancements in detection technology have led to increased research interest in viral uveitis.
Methods: This study conducted a comprehensive analysis, comprising a bibliometric examination of literature on virus and infectious uveitis and a retrospective study focusing on infectious uveitis. The bibliometric analysis aimed to elucidate past and emerging trends in this field over several decades.
Epidemiology, Clinical Features, and Molecular Basis of TTMV::RARA-driven Acute Promyelocytic Leukemia.
Blood
August 2025
Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, China.
Integration of torque teno mini virus (TTMV) generating the TTMV::RARA fusion represents a newly recognized subtype of acute promyelocytic leukemia (APL) that merits detailed investigation. We present the first comprehensive characterization of its epidemiologic profile, clinical presentation, virologic characteristics, and underlying molecular mechanisms. Our findings indicate that TTMV::RARA is more prevalent in pediatric patients and represents the second most common retinoic acid receptor fusion after PML::RARA.
View Article and Find Full Text PDF