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White horehound ( L.), is a grey-leaved perennial herb, belonging to Lamiaceae family, distributed in Eurasia and northern Africa. Despite the fact that has been used since ancient times in treating diverse diseases, it is only in the last decade or so that scientists have been able to lay the foundation for its potential pharmacological actions from the results observed through the prism of ethnopharmacological use of this species. The novelty of this study was that subcritical water extraction, acknowledged as a powerful extraction technology to recover phenolic compounds, was coupled with spray drying. The subcritical horehound extract, obtained using optimal process parameters, was used as a liquid feed in spray drying. Maltodextrin was used as a carrier in a concentration of 10%. Thus, two powders, carrier-free and 10% MD, were produced. Comprehensive powders characterization was conducted in order to evaluate their quality. Results confirmed that spray drying can be used as a method of choice for obtaining high quality horehound powders which kept the amorphous structure constant after 6 months.
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http://dx.doi.org/10.3390/pharmaceutics11100523 | DOI Listing |
Food Res Int
November 2025
Hainan University-HSF/LWL Collaborative Innovation Laboratory, College of Food Sciences & Engineering, Hainan University, 58 People Road, Haikou 570228, China; Haikou Key Laboratory of Special Foods, Haikou, Hainan 570228, China.
In this study, we explored the application of lactoferrin-(-)-epigallocatechin-3-gallate (LF-EGCG) complex with rapeseed, soybean, walnut, peanut and sesame oil for the preparation of Pickering emulsions and its spray-dried microcapsules. Spectroscopy and molecular docking revealed that LF-EGCG binds via hydrogen bonds, hydrophobic interactions, and van der Waals forces. Structural analysis demonstrated that 0.
View Article and Find Full Text PDFFood Res Int
November 2025
Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, 15551, United Arab Emirates. Electronic address:
Limosilactobacillus reuteri probiotics were encapsulated in Kudzu starch (KS) and Hemp protein (HP) complex coacervates (CC), followed by spray drying, to enhance their stability and boost their viability. The optimized conditions for CC consisted of a KS:HP ratio of 1:2 (w/w) and pH 5.0.
View Article and Find Full Text PDFFood Res Int
November 2025
German Federal Institute for Risk Assessment (BfR), Department Food Safety, National Reference Laboratory for Animal Protein in Feed, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address:
Processing food and feed sets off a variety of reactions (Maillard, (lipid) oxidation), which may be traced by covalent changes to e.g. proteins.
View Article and Find Full Text PDFFood Res Int
November 2025
Institute of Food Technology, Av. Brasil 2880, Jd. Chapadão, P.O. Box 139, Campinas, SP 13070-178, Brazil.
This study evaluated the feasibility of using ferrous sulfate microparticles (FSM), produced through the combination of spray drying and spray chilling techniques, to fortify plant-based yogurt and increase dietary iron intake. The stability of FSM was assessed, and iron bioavailability was estimated using the standardized INFOGEST in vitro digestion method, followed by Caco-2 cell culture assays. FSM showed moisture content and water activity (Aw <0.
View Article and Find Full Text PDFJ Drug Target
September 2025
Department of Pharmaceutics, ShriRam College of Pharmacy, Banmore, Morena-476444, Madhya Pradesh, India.
Tuberculosis (TB) continues to cause significant global mortality, highlighting the need for improved drug delivery systems. The objective of this paper focuses in describing the formulation, optimization and in vivo assessment of rifampicin encapsulated PLGA microparticles for site-specific inhalation therapy. Microparticles for inhalation were produced by spray drying, and the DoE methodology was applied to reach the most suitable aerodynamic properties (mass median aerodynamics diameter (MMAD) 2.
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