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Article Abstract
The long non-coding RNA (LncRNA) antisense RNA in the INK4 locus () is overexpressed in several cancers including breast cancer. To better understand the role of in breast cancer this study investigated where was expressed in breast tumors using hybridization by RNAscope. Additional RNAscope assays for , and were used to establish whether correlated with increased tumor promoting cytokines. Breast tumors with over expressed from real-time quantitative (RT-q) PCR assays were selected for analysis using RNAscope. All tumors showed expression in malignant cells, but amongst tumors showed different subcellular locations with 56% of tumors with only in the nucleus, 16% with only in the cytoplasm and 28% with in both the nucleus and cytoplasm. Cases with nuclear were positively correlated with expression in malignant cells (ρ = 0.57, = 0.0086), and no correlation was found between and or . Reduced was also found using siRNA to in MDA-MB-231 and MCF7 breast cancer cells. These data indicate that is expressed in malignant breast cells, and suggest its subcellular location may indicate its function in cancer progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749148 | PMC |
| http://dx.doi.org/10.3389/fonc.2019.00885 | DOI Listing |
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