Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Nucleoside antibiotics are a diverse class of natural products with promising biomedical activities. These compounds contain a saccharide core and a nucleobase. Despite the large number of nucleoside antibiotics that have been reported, biosynthetic studies on these compounds have been limited compared with those on other types of natural products such as polyketides, peptides, and terpenoids. Due to recent advances in genome sequencing technology, the biosynthesis of nucleoside antibiotics has rapidly been clarified. This review covering 2009-2019 focuses on recent advances in the biosynthesis of nucleoside antibiotics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41429-019-0236-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters.
Sci Adv
September 2025
Institut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.
Aminoglycosides (AGs) are broad-spectrum antibiotics effective against Gram-negative bacteria, with uptake dependent on membrane potential. However, the mechanisms of AG entry remain incompletely understood. Here, we identify a previously undescribed uptake pathway via carbohydrate transporters in .
View Article and Find Full Text PDFBiosynthesis of the Thiofuranose Core in Albomycin Requires a Versatile Enzyme AbmG That Catalyzes Net Dehydration via Cryptic Phosphorylation.
J Am Chem Soc
September 2025
Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Albomycins are unusual sulfur-containing nucleosides from the species of that exhibit potent antibiotic activities against both Gram-negative and Gram-positive bacteria including clinical pathogens. Previous studies demonstrated that the twitch radical SAM enzyme AbmM catalyzes an oxidative sulfur-for-oxygen swapping reaction converting CDP to a 4'-hydroxy-4'-thiocytidine 5'-diphosphate intermediate in the initial step of albomycin biosynthesis. However, the fate of this intermediate in the biosynthetic pathway has remained elusive.
View Article and Find Full Text PDFPopulation Pharmacokinetic Modeling Analysis of ASC10, a Novel Antiviral Agent Targeted COVID-19, in Chinese Healthy Subjects.
Drug Des Devel Ther
September 2025
Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Background: ASC10, an oral double prodrug of the antiviral ribonucleoside analog ASC10-A (also referred to as NHC), is currently in clinical trials for the treatment of COVID-19. Upon administration, ASC10 undergoes rapid biotransformation into the monoprodrug molnupiravir, which then swiftly converts to the active metabolite ASC10-A. Alternatively, ASC10 can directly transform into ASC10-A without forming molnupiravir as an intermediate.
View Article and Find Full Text PDFIdentification of potent antibacterial inhibitors targeting methyltransferase Mtr1/TrmD in Haemophilus influenzae via molecular dynamics simulations.
PLoS One
August 2025
Department of Pharmaceutics, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi, Saudi Arabia.
Bacterial influenza is a significant global health and economic concern, and the effectiveness of current therapies is declining as bacterial resistance increases. This case emphasizes the need for novel therapeutic approaches. A target-based method was used in this study to investigate the RNA 2'-O-methyltransferase MTr1/TrmD, an important enzyme involved in the pathogenic bacteria's cap-snatching mechanism.
View Article and Find Full Text PDFDiffuse pulmonary lesions caused by ANCA-associated vasculitis: A case report.
Medicine (Baltimore)
August 2025
Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China.
Rationale: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) encompasses rare, multisystem autoimmune diseases such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA. This group of vasculitides can manifest at any age, affecting various organ systems, with a notable frequency of respiratory involvement in GPA and microscopic polyangiitis. Pulmonary symptoms, often similar to those of respiratory infections, frequently complicate the diagnosis.
View Article and Find Full Text PDF