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To determine the impact of a new emergency medical services (EMS) 9-1-1 dispatch system on call-processing times for field-confirmed time-critical emergencies. An interrupted time series study compared 9-1-1 calls for field-confirmed emergencies processed by Los Angeles Fire Department (LAFD)-telecommunicators using either the Medical Priority Dispatch System® (January 1 - September 30, 2014) or the new Los Angeles Tiered Dispatch System (January 1 - September 30, 2015). Prior to the study, authors identified seven categories of time-critical emergencies. Cases meeting inclusion criteria were systematically identified using LAFD electronic health records, and the elapsed time from call receipt to key events were obtained. The primary outcome was call-processing time (CPT), defined as time from 9-1-1 call receipt to when resources were dispatched. During the study period, 12,439 incidents met inclusion criteria: 6,208 using MPDS and 6,231 using LA-TDS. Among all unique time-critical incidents, the mean CPT was 16 seconds faster using LA-TDS (M = 68.5) compared to MPDS (M = 84.4; p < 0.001). CPT was significantly (p < 0.01) lower using LA-TDS for: cardiac arrests with attempted resuscitation, patients requiring ventilation support, seizures requiring prehospital benzodiazepines, gunshot wounds with hypotension, automobile vs. pedestrian accidents, and long falls. There was no difference in CPT for drownings requiring resuscitation (p = 0.60). The elapsed time to arrival of first responders on scene improved from 370.1 seconds using MPDS to 354.8 seconds using LA-TDS (p < 0.001). The new Los Angeles Tiered Dispatch System significantly improved 9-1-1 call-processing times and total response times for nearly all identified time-critical emergencies under study.
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http://dx.doi.org/10.1080/10903127.2019.1668988 | DOI Listing |
Front Immunol
September 2025
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Background: Multiplex gene-edited chimeric antigen receptor (CAR) T-cell therapies face significant challenges, including potential oncogenic risks associated with double-strand DNA breaks. Targeted microRNAs (miRNAs) may provide a safer, functional, and tunable alternative for gene silencing without the need for DNA editing.
Methods: As a proof of concept for multiplex gene silencing, we employed an optimized miRNA backbone and gene architecture to silence T-cell receptor (TCR) and major histocompatibility complex class I (MHC-I) in mesothelin-directed CAR (M5CAR) T cells.
Am J Surg
August 2025
Emory University School of Medicine, USA; Grady Health System, USA. Electronic address:
Introduction: We sought to develop, implement and evaluate an urban prehospital whole blood (PH-WB) program.
Methods: Using retrospective heat map data, Quick Response Vehicles (QRVs) carrying PH-WB were strategically placed throughout the city and dispatched using dynamic deployment. Patient inclusion criteria were age ≥15 years, traumatic mechanism, and SBP ≤90 mmHg.
This paper presents a novel multiscale signal processing framework for power quality disturbance (PQD) and cyber intrusion detection in smart grids, combining Non-Subsampled Contourlet Transform (NSCT), Split Augmented Lagrangian Shrinkage Algorithm (SALSA), and Morphological Component Analysis (MCA). A key innovation lies in an adaptive weighting mechanism within NSCT's directional sub bands, enabling dynamic energy redistribution and enhanced representation of both low-frequency anomalies (e.g.
View Article and Find Full Text PDFClin Epidemiol
August 2025
Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.
Background: The Danish Prehospital Medical Record (DPMR) represents a pioneering nationwide electronic prehospital medical record system. While routinely collected data from the DPMR are increasingly used for research, a comprehensive description of its system and content is needed.
Objective: To provide an overview of the DPMR as a tool for research, including its structure, variables, and current volume of records.