Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm) should be replaced with TEER (Ω x cm).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734587PMC
http://dx.doi.org/10.1186/s12987-019-0151-8DOI Listing

Publication Analysis

Top Keywords

correction isogenic
4
isogenic neurovascular
4
neurovascular unit
4
unit model
4
model comprised
4
comprised human
4
human induced
4
induced pluripotent
4
pluripotent stem
4
stem cell-derived
4

Similar Publications

Traumatic brain injury (TBI) is the most important environmental risk factor for neurodegenerative disease. Tauopathy plays an important role in post-traumatic neurodegeneration. Human-induced pluripotent stem cell (hiPSC)-derived cortical organoids have exciting potential to reveal the influence of genotype on post-traumatic neurodegeneration because they permit manipulation of the genome in a human system.

View Article and Find Full Text PDF

Malignant B cells rely on B cell receptor (BCR) signals for their survival and growth. Besides the Immunoglobulin M (IgM) BCR, lymphoma cells can also express non-IgM (IgG) BCRs; however, the role of IgG BCRs in malignant B cell is not well understood. Here, we report poorer disease outcomes in diffuse large B cell lymphoma (DLBCL) expressing high IgM versus those expressing IgG1.

View Article and Find Full Text PDF

Hereditary Hemorrhagic Telangiectasia type 2 (HHT2) is a vascular disorder caused by mutations in ACVRL1. We generated human induced pluripotent stem cell (hiPSC) lines from two HHT2 patients with a heterozygous 1 bp deletion in exon 7 of ACVRL1 (c.1042delG) by reprogramming skin fibroblasts.

View Article and Find Full Text PDF

Precise correction of G6PD Viangchan mutation in iPSCs by prime editing strategy.

Sci Rep

August 2025

Oxidation in Red Cell Disorders Research Unit, Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, 154, Rama I Road, Patumwan district, Bangkok, 10330, Thailand.

Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency hold a significant risk of severe hemolytic crises under oxidative stress. Currently, the definitive and curative treatment for the disorder has not been developed. Among over 200 G6PD variants, G6PD Viangchan (c.

View Article and Find Full Text PDF

Parkinson's disease (PD) is a progressive, incurable neurodegenerative disorder characterized by the loss of neuromelanin (NM)-containing dopamine neurons (DAn) in the substantia nigra of the midbrain. Non-neuronal cells are increasingly recognized as contributors to PD. We generated human microglia-like cells (hMG) from induced pluripotent stem cells (iPSC) derived from patients with LRRK2 PD-causing mutations, gene-corrected isogenic controls, and healthy donors.

View Article and Find Full Text PDF