Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in rhesus monkeys. We measured infarct volume and neurological function by magnetic resonance imaging (MRI) and non-human primate stroke scale (NHPSS), respectively, to assess temporal changes following MCAO. Activated phagocytic microglia/macrophages were examined by immunohistochemistry in post-mortem brains (n=6 MCAO, n=2 controls) at 3 and 24 hours (acute stage), 2 and 4 weeks (subacute stage), and 4, and 20 months (chronic stage) following MCAO. We found that the infarct volume progressively decreased between 1 and 4 weeks following MCAO, in parallel with the neurological recovery. Greater presence of cluster of differentiation 68 (CD68)-expressing microglia/macrophages was detected in the infarct lesion in the subacute and chronic stage, compared to the acute stage. Surprisingly, 98~99% of transforming growth factor beta (TGFβ) was found co-localized with CD68-expressing cells. CD68-expressing microglia/macrophages, rather than CD206 cells, may exert anti-inflammatory effects by secreting TGFβ after the subacute stage of ischemic stroke. CD68 microglia/macrophages can therefore be used as a potential therapeutic target.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751863 | PMC |
| http://dx.doi.org/10.5607/en.2019.28.4.458 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A quest for understanding: older migrants' wellbeing beyond integration in Sweden.
Front Public Health
September 2025
Department of Health Care Sciences, Marie Cederschiöld University, Stockholm, Sweden.
Purpose: This study investigates how older foreign-born adults in Sweden experience and navigate social connectedness as a determinant of wellbeing.
Methods: Employing Glaser's grounded theory methodology, we collected qualitative data through individual ( = 1) and focus group ( = 5) interviews with 23 participants aged 60 + representing four distinct cultural-linguistic groups: Arabic, Finnish, Spanish, and Chinese speakers.
Results: The analysis identified "" as the core category, encompassing three dimensions: (1) , (2) , and (3) .
Comparison of EEG Burst Suppression and Hemodynamic Effects Between Remimazolam Tosilate and Etomidate During General Anesthesia Induction: A Retrospective Analysis.
Drug Des Devel Ther
September 2025
Department of Anesthesiology, The Second People's Hospital of Guiyang, The Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang, People's Republic of China.
Background: Remimazolam tosilate, a novel ultra-short-acting benzodiazepine, demonstrates promising safety profiles in clinical settings. While both remimazolam tosilate and etomidate provide hemodynamic stability during anesthesia induction, limited research has directly compared their effects on electroencephalogram (EEG) burst suppression (periods of transient brain wave silence), a potential predictor of adverse neurological outcomes. This study aims to compare the incidence rate of EEG burst suppression (ESR) with remimazolam tosilate versus etomidate by reviewing the drug regimens used by different anesthesiologists in clinical practice.
View Article and Find Full Text PDFLiver Fibrosis and Quality of Life in Liver Transplant Recipients Over 10 Years: A Cross-Sectional Study Using Transient Elastography.
Exp Clin Transplant
August 2025
>From the Department of Gastroenterology, Dokuz Eylul University Hospital, Izmir, Türkiye.
Objectives: Liver transplant has significantly improved the survival of patients with end-stage liver disease, yet long-term transplant recipients often face challenges related to graft function and well-being. We aimed to evaluate the clinical role of vibration-controlled transi-ent elastography for assessment of liver fibrosis and steatosis, with a focus on fibrosis and steatosis, in liver transplant recipients who were over 10 years posttrans-plant. In addition, we aimed to identify factors that influence liver function and quality of life in these patients.
View Article and Find Full Text PDFIn this paper, we will present an analysis of three terms central to contemporary cultural critique: age, gender and migration, bringing them together in an approach we call "triangulation". We draw on Katy Gardner's ethnographic study of Bangladeshi migrants to London, Age, Narrative and Migration (2002), which addresses the three terms, to examine the interrelated identity constructions that are at stake in triangulation. In a second step, we analyze Monica Ali's novel Brick Lane (2003) as a pertinent literary example, in which aspects of age, gender, and migration come together in ways that may further illuminate and develop these as terms of cultural critique.
View Article and Find Full Text PDFCortical response to transient and long-term visual field loss.
Cereb Cortex
August 2025
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss.
View Article and Find Full Text PDF