Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed retinal imaging using modulated raster and circular scans in both mice and humans. We compared speckle-reduced vis-OCT images with the images acquired with unmodulated B-scans from the same anatomical locations. We compared contrast-to-noise ratio (CNR) and equivalent number of looks (ENL) to quantify the image quality enhancement. Speckle-reduced images showed up to a 2.35-dB improvement in CNR and up to a 3.1-fold improvement in ENL with more discernable anatomical features using eight modulated A-line averages at a 25-kHz A-line rate.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718816 | PMC |
| http://dx.doi.org/10.1117/1.NPh.6.4.041107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mavacamten effectively reduces > 100 mmHg left ventricular outflow tract gradients As early as one week of treatment in obstructive hypertrophic cardiomyopathy.
Int J Cardiol
September 2025
Division of Non-Invasive Cardiology, Cardiology Centre, Department of Medicine, University of Szeged, Hungary. Electronic address:
Background: Real-world data on the efficacy of mavacamten, indicated for the treatment of obstructive hypertrophic cardiomyopathy (oHCM), are relatively scarce, particularly in patients with extreme left ventricular outflow tract (LVOT) gradients and concerning its short-term effects.
Patients/methods: We investigated a cohort of twenty-five oHCM patients [15 men (60 %), mean age: 55 ± 11 years], with a resting or provoked LVOT gradient of >100 mmHg, receiving mavacamten treatment. Patients underwent a complete standard and 2D-speckle tracking echocardiographic examination after one week (W1) of treatment initiation and at subsequent four-week intervals.
Prognostic Effect of Left Atrial Function by Three-Dimensional Speckle-Tracking Echocardiography on Adverse Pregnancy Outcomes in Patients With Hypertensive Disorders of Pregnancy: A Preliminary Study.
Echocardiography
September 2025
Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Objective: To evaluate the left atrial function in pregnant women with hypertension versus those with normotension using three-dimensional speckle tracking echocardiography (3D-STE) and investigate the association between left atrial dysfunction and adverse pregnancy outcomes.
Methods: A total of 94 pregnant women registered at the Tiantan Hospital between August 2023 and October 2024 who underwent comprehensive prenatal exams were enrolled. They were divided into three groups according to their blood pressure: gestational hypertension (GH), preeclampsia (PE), and normotensive control groups.
Dual Disruption of Embryonic Angiogenesis by Hyperglycemia: Structural and Hemodynamic Alterations Revealed via OCT Angiography and Biospeckle Imaging in the Chick CAM Model.
Microcirculation
October 2025
Biophotonics Lab, Department of Bioengineering and Biotechnology, Birla Institute of Technology, Ranchi, Jharkhand, India.
Objective: This study investigates the effects of hyperglycemia on vascular morphology and hemodynamics during embryogenesis using the chick chorioallantoic membrane (CAM) model.
Methods: We employed a dual-modality, label-free imaging approach, Optical Coherence Tomography Angiography (OCTA) and biospeckle imaging, to evaluate microvascular architecture and real-time flow dynamics in chick embryos subjected to hyperglycemic conditions. Quantitative metrics such as vessel area, branching junctions, lacunarity, and biospeckle contrast were analyzed to assess angiogenic and metabolic responses.
Isometric exercise training in patients with heart failure with preserved ejection fraction: A randomised controlled study.
Eur J Prev Cardiol
August 2025
Department of Cardiology, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London, UK.
Aim: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical condition associated with poor health-related quality of life and high mortality rates. Limited therapeutic options highlight the need for innovative approaches. Isometric exercise training (IET) produces cardiovascular benefits; however, the effects of IET in patients with HFpEF have not yet been studied.
View Article and Find Full Text PDFExploring the effects of capsule in microcirculatory dysfunction model rats through laser speckle contrast imaging and metabolomics.
Front Pharmacol
August 2025
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine (Institute of Traditional Chinese Medicine), Guangdong Pharmaceutical University, Guangzhou, China.
Background: Microcirculatory dysfunction leads to a number of diseases and worsen prognosis. Blood-activating drugs like capsule may improve circulation, but its pharmacological effects in microcirculatory dysfunction remain unclear.
Objective: The purpose of this study is to determine the pharmacological effect of capsules in treating microcirculatory dysfunction.