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http://dx.doi.org/10.1038/d41586-019-02609-1 | DOI Listing |
BMC Genomics
July 2025
Fang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, Ocean University of China, Qingdao, 266003, China.
Background: Histones are the basic packaging units of eukaryotic DNA and are essential for the dynamics of chromatin and the regulation of epigenetics. Canonical histones and their variants exhibit important functional differences in biological processes. However, little is known about the role of histone family members in molluscs, which are known for their ecological and morphological diversity.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2024
Department of Biological Sciences, The George Washington University, Washington, DC 20052.
Mar Biotechnol (NY)
October 2024
Department of Psychology, University of Illinois, Champaign, IL, 61820, USA.
The common clownfish, Amphiprion ocellaris, is an iconic coral reef fish, ubiquitous in the marine aquarium hobby and useful for studying a variety of biological processes (e.g., mutual symbiosis, ultraviolet vision, and protandrous sex change).
View Article and Find Full Text PDFMol Biol Evol
August 2024
European Molecular Biology Laboratory, Heidelberg, Germany.
Understanding the evolutionary potential of mutations in gene regulatory networks is essential to furthering the study of evolution and development. However, in multicellular systems, genetic manipulation of regulatory networks in a targeted and high-throughput way remains challenging. In this study, we designed TF-High-Evolutionary (HighEvo), a transcription factor (TF) fused with a base editor (activation-induced deaminase), to continuously induce germline mutations at TF-binding sites across regulatory networks in Drosophila.
View Article and Find Full Text PDFFront Cell Dev Biol
June 2023
Division of Anthropology, Institute of Organismic and Molecular Evolution, Faculty of Biology, Johannes Gutenberg University Mainz, Mainz, Germany.