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Selective detection of biothiols holds prime importance owing to the role of varied concentrations of biothiols in various diseases, thus demanding extensive research for developing materials toward selective sensing. In this study, we targeted postsynthetic modification (PSM) approach for imparting desired functionality to chemically stable UiO-66-NH metal-organic framework, which exhibits highly selective sensing toward biothiols. The appended dinitrobenzenesulfonyl group reacts with biothiols via chemidosimetric approach. As a consequence, the probe exhibits a turn on response, which holds immense importance for facile biological studies.
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http://dx.doi.org/10.1021/acsomega.7b01891 | DOI Listing |
ACS Sens
September 2025
College of Chemistry, Beijing Normal University, Beijing 100875, China.
Dopamine (DA) signaling is essential for neurodevelopment and is particularly sensitive to disruption during adolescence. Protein restriction (PR) can impair DA dynamics, yet mechanistic insights remain limited due to challenges in real-time neurochemical sensing. Here, we present aptCFE, a robust implantable aptamer-based sensor fabricated via a reagent-free, 3 min electrochemical conjugation (E-conjugation) using amine-quinone chemistry.
View Article and Find Full Text PDFACS Sens
September 2025
School of Physics and Electric Engineering, Linyi University, Linyi 276000, China.
In this study, employing a 2D electrodeposition in situ assembly method, a high-performance HS sensor based on a p-n type CuO-CuFeO heterostructure ordered nanowire arrays was successfully fabricated on silicon substrates. Compared to CuO, CuO-CuFeO nanowire arrays exhibits an ideal interfacial barrier structure and higher initial resistance, with a response to 10 ppm of HS at room temperature (20 ± 3 °C) increased by 225 times and a response time reduced by over 2400 s. The sensor demonstrates exceptional sensitivity (LOD = 10 ppb; response = 234.
View Article and Find Full Text PDFNano Lett
September 2025
Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore.
Precise delivery of nanoliter-scale reagents is essential for high-throughput biochemical assays, yet existing platforms often lack real-time control and selective content fusion. Conventional methods rely on passive encapsulation or stochastic pairing, limiting both throughput and biochemical specificity. Here, we introduce an on-demand nanoliter delivery platform that seamlessly integrates electrical sensing, triggered droplet merging, and passive sorting in a single continuous flow.
View Article and Find Full Text PDFACS Sens
September 2025
METU MEMS Center, Ankara 06530, Türkiye.
Cardiovascular diseases (CVDs) remain a leading cause of death, particularly in developing countries, where their incidence continues to rise. Traditional CVD diagnostic methods are often time-consuming and inconvenient, necessitating more efficient alternatives. Rapid and accurate measurement of cardiac biomarkers released into body fluids is critical for early detection, timely intervention, and improved patient outcomes.
View Article and Find Full Text PDFPsychol Health
September 2025
Institute of Applied Health Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK.
Objective: There is a lack of research on how illness representations as represented in the Common Sense Self-Regulation Model (CS-SRM) emerge and develop. We aimed to describe the evolution of COVID-19 illness representations over time, and to explore associations with sociodemographic characteristics and protective behaviours.
Methods And Measures: This study (June 2020 release from lockdown to February 2021 after vaccine roll-out) used 17 independently recruited cross-sectional cohorts.