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Article Abstract
Background: Anti-carbohydrate antibody responses, including those of anti-blood group ABO antibodies, are yet to be thoroughly studied in humans. Because anti-ABO antibody-mediated rejection is a key hurdle in ABO-incompatible transplantation, it is important to understand the cellular mechanism of anti-ABO responses. We aimed to identify the main human B cell subsets that produce anti-ABO antibodies by analyzing the correlation between B cell subsets and anti-ABO antibody titers.
Methods: Blood group A-binding B cells were analyzed in peritoneal fluid and peripheral blood samples from 43 patients undergoing peritoneal dialysis and 18 healthy volunteers with blood group B or O. The correlation between each blood group A-specific B cell subset and anti-A antibody titer was then analyzed using Pearson's correlation analysis.
Results: Blood group A-binding B cells were enriched in CD27CD43CD1c B1, CD5 B1, CD11b B1, and CD27CD43CD1c marginal zone-B1 cells in peripheral blood. Blood group A-specific B1 cells (=0.029 and R=0.356 for IgM; =0.049 and R=0.325 for IgG) and marginal zone-B1 cells (=0.011 and R=0.410 for IgM) were positively correlated with anti-A antibody titer. Further analysis of peritoneal B cells confirmed B1 cell enrichment in the peritoneal cavity but showed no difference in blood group A-specific B1 cell enrichment between the peritoneal cavity and peripheral blood.
Conclusions: Human B1 cells are the key blood group A-specific B cells that have a moderate correlation with anti-A antibody titer and therefore constitute a potential therapeutic target for successful ABO-incompatible transplantation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713656 | PMC |
| http://dx.doi.org/10.3343/alm.2020.40.1.48 | DOI Listing |
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