Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

The use of culture methods to detect diversity does not provide sufficient resolution to identify strains present at low levels. Here, we target the hypervariable gene and describe a database containing 534 distinct partial sequences and associated O groups for use with culture-independent community analysis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696633PMC
http://dx.doi.org/10.1128/MRA.00476-19DOI Listing

Publication Analysis

Top Keywords

partial sequences
8
gnddb database
4
database partial
4
sequences assist
4
assist analysis
4
analysis escherichia
4
escherichia coli
4
coli communities
4
communities high-throughput
4
high-throughput sequencing
4

Similar Publications

Immunogenicity and protection against infectious bursal disease via a transgenic Eimeria acervulina expressing IBDV VP2-2C3d fusion protein.

Vaccine

September 2025

State Key Laboratory of Veterinary Public Health and Safety; Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, National Animal Protozoa Laboratory & College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address:

Infectious bursal disease (IBD), caused by the infectious bursal disease virus (IBDV), significantly threatens global poultry health by inducing immunosuppression and causing economic losses. To enhance vaccination efficacy, we engineered a transgenic strain of Eimeria acervulina (Ea-2C3d) expressing a fusion protein composed of IBDV VP2 and three tandem C3d segments (3C3d), utilizing C3d's adjuvant properties to boost immune responses. The transgene was generated by integrating codon-optimized VP2 and 3C3d sequences into the E.

View Article and Find Full Text PDF

Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.

Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.

View Article and Find Full Text PDF

Background: Parkinson's disease (PD) often presents with lateralized motor symptoms at onset, reflecting asymmetric degeneration of the substantia nigra (SN). Neuromelanin (NM) loss and iron accumulation are hallmarks of SN pathology in PD, but their spatial distribution and interrelationship in PD patients with right-sided (PDR) or left-sided (PDL) motor symptom onset remain unclear.

Purpose: To investigate the spatial vulnerability and interrelationship of NM and iron in the SN among PDR, PDL, and healthy controls (HCs) using MRI.

View Article and Find Full Text PDF

Despite recent advances in neoadjuvant strategies for locally advanced rectal cancer (LARC), optimal chemotherapy regimens and the role of genetic biomarkers in guiding treatment remain unclear. Moreover, predictive markers are urgently needed for radiation-sparing strategies. Therefore, we aimed to assess the predictive and prognostic value of TP53, KRAS, and APC mutations in patients with LARC undergoing neoadjuvant chemotherapy (NACT) by retrospectively analyzing 43 patients with LARC who underwent NACT without radiation.

View Article and Find Full Text PDF

Introduction: is a well-recognized etiologic agent of upper respiratory tract disease in tortoises. Although frequently reported in both captive and wild populations across Europe, its occurrence in Portugal had not been previously documented. This study aimed to investigate the presence of in apparently healthy captive tortoises in mainland Portugal and to evaluate potential host- and management-related factors associated with infection.

View Article and Find Full Text PDF