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Nitrogen dioxide (NO) remains an important traffic-related pollutant associated with both short- and long-term health effects. We aim to model daily average NO concentrations in Switzerland in a multistage framework with mixed-effect and random forest models to respectively downscale satellite measurements and incorporate local sources. Spatial and temporal predictor variables include data from the Ozone Monitoring Instrument, Copernicus Atmosphere Monitoring Service, land use, and meteorological variables. We derived robust models explaining ∼58% ( range, 0.56-0.64) of the variation in measured NO concentrations using mixed-effect models at a 1 × 1 km resolution. The random forest models explained ∼73% ( range, 0.70-0.75) of the overall variation in the residuals at a 100 × 100 m resolution. This is one of the first studies showing the potential of using earth observation data to develop robust models with fine-scale spatial (100 × 100 m) and temporal (daily) variation of NO across Switzerland from 2005 to 2016. The novelty of this study is in demonstrating that methods originally developed for particulate matter can also successfully be applied to NO. The predicted NO concentrations will be made available to facilitate health research in Switzerland.
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http://dx.doi.org/10.1021/acs.est.9b03107 | DOI Listing |
Brief Bioinform
August 2025
College of Pharmacy, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, P. R. China.
Drug-induced hepatotoxicity (DIH), characterized by diverse phenotypes and complex mechanisms, remains a critical challenge in drug discovery. To systematically decode this diversity and complexity, we propose a multi-dimensional computational framework integrating molecular structure analysis with disease pathogenesis exploration, focusing on drug-induced intrahepatic cholestasis (DIIC) as a representative DIH subtype. First, a graph-based modularity maximization algorithm identified DIIC risk genes, forming a DIIC module and eight disease pathogenesis clusters.
View Article and Find Full Text PDFJ Proteome Res
September 2025
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610207, China.
Myasthenia gravis (MG) presents significant health and economic challenges. To identify novel biomarkers, we analyzed proteomic data from 52,704 UK Biobank individuals, focusing on 1463 baseline proteins with follow-up >10 years. Baseline and potential MG cases were 1:5 matched to controls by using propensity score matching.
View Article and Find Full Text PDFClin Exp Immunol
September 2025
Orthopedic Center, Sunshine Union Hospital, High-tech Zone, Weifang City, Shandong Province, China.
Introduction: We attempted to perform a comprehensive bioinformatics analyses on osteoarthritis (OA) based on the NKT-related genes and explore the clinical related critical genes.
Methods: Differentially expressed genes (DEGs) and NKT-related genes from WGCNA were obtained using the dataset GSE114007, followed by intersection analysis to obtain NKT-related DEGs. Lasso regression, support vector machine and random forest were performed to screen feature genes, followed by verification with ROC curve, and nomogram model.
Front Oncol
August 2025
Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Objective: To develop a deep learning radiomics(DLR)model integrating PET/CT radiomics, deep learning features, and clinical parameters for early prediction of bone oligometastases (≤5 lesions) in breast cancer.
Methods: We retrospectively analyzed 207 breast cancer patients with 312 bone lesions, comprising 107 benign and 205 malignant lesions, including 89 lesions with confirmed bone metastases. Radiomic features were extracted from computed tomography (CT), positron emission tomography (PET), and fused PET/CT images using PyRadiomics embedded in the uAI Research Portal.
Chem Sci
August 2025
College of Materials Science and Engineering, College of Science, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University Nanjing 210037 China
J-Aggregates hold significant promise for high-resolution shortwave infrared (SWIR) imaging, yet achieving robust SWIR absorption and emission simultaneously has been hindered by hypsochromic shifts in absorption and emission quenching caused by undesirable H- and random aggregation. To address this, we developed highly fluorescent BODIPY J-aggregates exhibiting absorption and emission spanning 1000-1600 nm. A key innovation was the implementation of a zig-zag molecular design, which effectively suppressed H-aggregation and minimized intermolecular interactions, thereby enabling anti-quenching SWIR emission.
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