Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Long pentraxin 3 (PTX3) is produced by various cell types and is correlated with tumor progression in various tumor types. However, the clinical significance of polymorphisms in oral cancer and their correlation with the risk of cancer are still unclear. In this study, we assessed the influence of gene polymorphisms and environmental factors on susceptibility to oral tumorigenesis. We recruited 865 cases with oral cancer and 1,189 controls. Four single-nucleotide variations of the gene (rs1840680, rs2305619, rs3816527, and rs2120243) were verified using a real-time polymerase chain reaction in control participants and cases with oral cancer. We found that rs3816527 in smokers was correlated with the development of late-stage cancer (odds ratio [OR], 2.328; 95% confidence interval [CI], 1.078-5.027) and increased lymph node metastasis (OR, 2.152; 95% CI, 1.047-4.422). Moreover, additional bioinformatics analysis results showed that the rs3816527 C allele variant to the A allele exhibited the strongest exonic splicing enhancer activity. In conclusion, our results suggested that rs3816527 plays a role in oral cancer development.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616059 | PMC |
| http://dx.doi.org/10.3389/fonc.2019.00581 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Alcohol Consumption on Selected Cancer Incidence Trends Among Adults in the United States, 2008-2019.
Cancer Epidemiol Biomarkers Prev
September 2025
National Cancer Institute, Bethesda, MD, United States.
Background: Alcohol consumption is a risk factor for certain cancers and is increasing in the United States. We estimated the impact of alcohol consumption on cancer incidence trends in the United States from 2008-2019 across six alcohol-related cancers among men and women.
Methods: Average daily alcohol consumption (ADC) was calculated from the National Health Interview Survey (NHIS, 1998-2009) and adjusted to per capita sales data to account for underreporting alcohol use.
Myoepithelial Carcinoma Ex-Pleomorphic Adenoma Exposing a RET Germline Mutation: A Rare Genetic Event.
Head Neck Pathol
September 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Myoepithelial carcinoma (MECA) is a malignant neoplasm composed exclusively of myoepithelial cells and accounts for less than 1% of all salivary gland tumors. Its diagnosis is often challenging due to histologic overlaps with benign lesions and its variable morphologic presentation. Although molecular profiling has emerged as a valuable tool in salivary gland tumor classification, the genetic landscape of MECA remains incompletely defined.
View Article and Find Full Text PDFPerspectives on two major bioactives in ginger, 6-gingerol and 6-shogaol, focusing on the metabolic fate and bioactivities.
Crit Rev Food Sci Nutr
September 2025
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.
Ginger, a globally cultivated spice and medicinal herb, is renowned for its health benefits and distinctive flavor. As ginger's main pungent and bioactive components, 6-gingerol and 6-shogaol share similar physicochemical properties and can be obtained by extraction from ginger or chemical synthesis. After oral ingestion, the biological fate of 6-gingerol and 6-shogaol are influenced by processes including absorption, biotransformation, distribution, and excretion.
View Article and Find Full Text PDFStanford Type A Aortic Dissection During Adjuvant Capecitabine Chemotherapy for Colorectal Cancer.
JACC Case Rep
September 2025
Department of Cardiovascular Surgery, Nagoya Heart Center, Nagoya, Japan.
Background: Capecitabine, an oral prodrug of 5-fluorouracil, is widely used for gastrointestinal malignancies. While its coronary toxicity is well documented, large-vessel complications such as aortic dissection are rarely reported.
Case Summary: We present a 65-year-old man with colorectal cancer who developed Stanford type A aortic dissection 3 days after initiating adjuvant capecitabine therapy.
Perioperative Management of Carotid Blowout Syndrome After Head and Neck Cancer Treatment: A Retrospective Case Series.
J Neurosurg Anesthesiol
September 2025
Anesthesiology, University of Michigan, Ann Arbor, MI.
Background: Carotid blowout syndrome (CBS) is a life-threatening emergency involving the rupture of the carotid arteries and/or branches, often following surgery and radiotherapy for head and neck cancer. Our case series aimed to describe airway management strategies, endovascular and surgical approaches, perioperative resuscitation management, and clinical outcomes in a cohort of patients with CBS at a tertiary referral academic health center.
Methods: We retrospectively identified patients presenting with CBS between 2017 and 2021.