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Article Abstract
We report a synthetic route toward a family of functional COS/HS-releasing N-substituted N-thiocarboxyanhydrides (NTAs) with functionalities to accommodate popular conjugation reactions, including olefin cross metathesis, thiol-ene, and copper-catalyzed azide-alkyne cycloaddition. The N-substituted NTAs were attached to small molecules, polymers, and a protein to synthesize novel HS donors convergently. All conjugates showed sustained HS release kinetics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911359 | PMC |
| http://dx.doi.org/10.1021/acschembio.9b00248 | DOI Listing |
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