Publications by authors named "Mohammed Alaboalirat"
Aqueous Self-Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers.
Angew Chem Int Ed Engl
June 2025
The self-assembly of amphiphilic bottlebrush block copolymers (BCPs), featuring backbones densely grafted with two types of side chains, is less well understood compared to linear BCPs. In particular, the solution self-assembly of tapered bottlebrush BCPs-cone-shaped BCPs with hydrophilic or hydrophobic tips-remains unexplored. This study investigates eight tapered and four cylindrical bottlebrush BCPs with varied ratios of hydrophobic polystyrene (PS) and hydrophilic poly(acrylic acid) (PAA) side chains, synthesized via sequential addition of macromonomers using ring-opening metathesis polymerization (SAM-ROMP).
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- The study addresses the difficulty of synthesizing polymers with densely packed cyclodextrin units, specifically poly(β-cyclodextrin), using ring-opening metathesis polymerization and Grubbs catalyst, achieving molecular weights over 10 g/mol and a low dispersity.
- In aqueous solution, β-cyclodextrin interacts with adamantyl groups to form host-guest complexes, facilitating the creation of supramolecular polymer networks.
- These networks, composed of poly(β-CD) and adamantyl-functionalized poly(2-hydroxyethyl acrylate), were dried into transparent films, allowing for structure-property analysis through tensile measurements.
We report a synthetic route toward a family of functional COS/HS-releasing N-substituted N-thiocarboxyanhydrides (NTAs) with functionalities to accommodate popular conjugation reactions, including olefin cross metathesis, thiol-ene, and copper-catalyzed azide-alkyne cycloaddition. The N-substituted NTAs were attached to small molecules, polymers, and a protein to synthesize novel HS donors convergently. All conjugates showed sustained HS release kinetics.
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