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Objective: The optimal management of dural closure is unclear; therefore, we aimed to survey current common practices among Italian practitioners.
Methods: The Delphi method was used to achieve a consensus on dura mater closing techniques in Italy. A steering committee decided 3 major topics to be investigated: pre- and postoperative conditions associated with cerebrospinal fluid (CSF) leak, indications to perform watertight dural closure, and dural closure technique. A questionnaire containing 12 statements was then submitted to Italian neurosurgeons.
Results: The response rate was 60%. Among 60 items, 36 reached a positive consensus, 5 reached a negative consensus, and 19 did not reach consensus. Intrathecal hypertension, arachnoid opening, previous treatments, spinal incidental durotomy, wide size of osteo-dural defect, and lack of nasoseptal flap were considered major risk factors for CSF leak. Early mobilization, avoidance of stress maneuvers, and use of CSF external drainage were considered to reduce CSF leak rate. Italian neurosurgeons always attempt watertight dural closure, ideally with monofilament nonabsorbable sutures. Both autologous and heterologous dural grafts are used. Among dural sealants, fibrin glues are preferred, which are used most commonly in transsphenoidal surgery.
Conclusions: This study elucidates the areas of consensus and uncertainty on dural closure management among a group of Italian neurosurgeons. It provides reliable and comparable data for the investigation of the departments' daily practice in dural closure. Given the lack of solid evidence, there is a need for further comparative studies of dural repair strategies.
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http://dx.doi.org/10.1016/j.wneu.2019.05.125 | DOI Listing |
Neurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Tokyo Medical University.
Adhesive materials are widely used in microvascular decompression for treating neurovascular compression syndromes. They play an important role in the critical step of vessel fixation. Recently, completely autologous fibrin glue produced solely from a patient's own plasma was developed.
View Article and Find Full Text PDFCureus
July 2025
General Internal Medicine, King's Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, GBR.
A man in his 70s with known vascular risk factors presented with acute onset of bilateral lower limb weakness and urinary retention. Initial spinal magnetic resonance imaging (MRI) revealed a longitudinally extensive myelopathy. It was initially interpreted as transverse myelitis, prompting treatment with high-dose corticosteroids.
View Article and Find Full Text PDFCureus
July 2025
Neurosurgery, Hamad Medical Corporation, Doha, QAT.
This systematic review evaluates the management of cerebrospinal fluid (CSF) leaks following traumatic skull base fractures and examines the associated risk of post-traumatic meningitis (PTM). It also critically investigates the debated hypothesis that meningitis may promote spontaneous closure of defects in the dura mater through inflammation-induced healing. A comprehensive literature search was performed using PubMed, Scopus, and the Cochrane Library according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2025
School of Microelectronics, Shanghai University, Shanghai 201800, China.
Dural closure with a replacement is a crucial procedure in neurosurgery. Conventional dura mater substitutes derived from collagen often exhibit low mechanical strength and strong adhesion to the brain tissue, leading to complications such as cerebrospinal fluid leakage, brain adhesion, and intracranial infection. Silk fibroin extracted from silkworms () can be used as an ideal substitute for dura mater with excellent histocompatibility, degradability, and tunable mechanical strength.
View Article and Find Full Text PDFBrain Spine
August 2025
Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Introduction: Full-endoscopic spinal surgery (monoportal endoscopy) has emerged as a minimally invasive alternative for managing intradural spinal pathologies, offering reduced morbidity and accelerated recovery compared to conventional techniques.
Research Question: What is the current evidence on the effectiveness, limitations, and future prospects of full-endoscopic spinal surgery for intradural pathologies?
Material And Methods: A systematic review following PRISMA guidelines was conducted. Electronic databases (Cochrane, OVID-MEDLINE, PubMed, Embase, Web of Science, Scopus) were searched for studies published from 2000 to 2024.