Publications by authors named "Tugrul Cem Unal"

Introduction: Full-endoscopic spinal surgery (monoportal endoscopy) has emerged as a minimally invasive alternative for managing intradural spinal pathologies, offering reduced morbidity and accelerated recovery compared to conventional techniques.

Research Question: What is the current evidence on the effectiveness, limitations, and future prospects of full-endoscopic spinal surgery for intradural pathologies?

Material And Methods: A systematic review following PRISMA guidelines was conducted. Electronic databases (Cochrane, OVID-MEDLINE, PubMed, Embase, Web of Science, Scopus) were searched for studies published from 2000 to 2024.

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Background And Objectives: Effective reconstruction of skull base defects after endonasal endoscopic surgery is essential to prevent complications such as cerebrospinal fluid leakage and infection. Traditional methods may not always provide optimal outcomes for certain defects. This study evaluates the feasibility of using the Amplatzer Septal Occluder (ASO) as an adjunctive tool for skull base reconstruction in a cadaveric model.

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Background And Objectives: Neurosurgical education requires meticulous training tools that offer realistic haptic feedback and are, ideally, cost-effective. The current training models, including cadaveric specimens and high-fidelity simulators, are often expensive, inaccessible, and single-use, limiting their adoption in resource-constrained settings. To address this gap, we developed a novel, ultra-low-cost, reusable brain tumor resection model with realistic haptic feedback and photograph-based navigation.

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Introduction: This study evaluates hippocampal dosimetry and neurocognitive outcomes in patients undergoing Gamma Knife radiosurgery (GKRS) for benign sellar, parasellar, and suprasellar lesions. While hippocampal protection has been well studied in whole-brain radiotherapy (WBRT), its relevance in stereotactic radiosurgery (SRS) remains underexplored. This study systematically investigates hippocampal radiation dose thresholds and associated neurocognitive outcomes in patients undergoing single-fraction Gamma Knife radiosurgery specifically for benign sellar and parasellar lesions.

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Purpose: Despite the benefits over classical microdiscectomy, Full endoscopic lumbar discectomy (FELD) has been associated with complications attributed to changes in intracranial pressure (ICP). This study aimed to assess intracranial and epidural pressure changes at different spinal levels induced by continuous irrigation during FELD.

Materials And Methods: Eight fresh cadavers (ages 41-78) devoid of cranial or spinal trauma were utilized.

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Aim: To analyze the epidemiologic, clinical, neuroradiological, and histopathological data of patients who have undergone anterior temporal lobectomy (ATL) for drug-resistant mesial temporal lobe epilepsy (MTLE).

Material And Methods: The study included patients who were diagnosed with MTLE refractory to medical treatment, underwent anterior temporal lobectomy at our institution between 2010 and 2020 and had postoperative clinical follow-up data. The epidemiologic, clinical, neuroradiological, and histopathological data of the patients were collected.

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Background: Bilateral inferior colliculus (IC) infarction is a rare condition that can lead to severe auditory deficits. Cerebellar arteriovenous malformations (AVMs) treated with endovascular embolization pose a risk for ischemic complications affecting the brainstem.

Observations: A 54-year-old male presented with intermittent headaches and imbalance, and, following a fall, a subarachnoid hemorrhage and cerebellar AVM were identified.

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Aim: To compare the treatment outcomes of surgical and endovascular methods in patients with intracranial aneurysms.

Material And Methods: A total of 1183 patients [722 (61%)] female and 461 [(39%) male] with intracranial aneurysms, including 615 with subarachnoid hemorrhage (SAH) and 568 without hemorrhage, were retrospectively reviewed.

Results: The mean age of patients was 51.

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Aim: To investigate the effectiveness of local halofuginone application for spinal epidural fibrosis (EF) after lumbar laminectomy in rats.

Material And Methods: Forty rats were equally divided into four groups (Groups I-IV; 10 rats in each group), and lumbar laminectomy was performed under general anesthesia. After laminectomy, Group I received saline (NaCl 0.

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Introduction: Pediatric epilepsy surgery is an effective treatment modality for patients with drug-resistant epilepsy (DRE). Early pediatric surgery yields favorable results for DRE in terms of seizure control and neurophysiological outcome. In this study, pediatric patients were categorized based on their age (above 3 years old and below 3 years old) to demonstrate the effectiveness and safety of surgical procedures.

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Background And Importance: Full-endoscopic techniques are well-described for spinal procedures. Although endoscopic-assisted techniques are reported for posterior fossa decompression (PFD) in Chiari malformation (CM), a full-endoscopic technique is yet to be reported in these patients. The aim of this study was to present and describe a full-endoscopic technique for PFD in patients with CM.

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Introduction: Colloid cysts (CCs) are rare benign lesions that usually arise from the roof of the third ventricle. They may present with obstructive hydrocephalus and cause sudden death. Treatment options include ventriculoperitoneal shunting, cyst aspiration, and cyst resection microscopically or endoscopically.

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Background: Subdural empyemas (SDEs) are rare intracranial infections mostly secondary to sinusitis. Incidence of SDEs is 5-25%. Interhemispheric SDEs are even rarer, which makes their diagnosis and treatment difficult.

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Aim: To describe, and to evaluate the clinical and radiological characteristics of pediatric cavernous malformations (CMs) and the surgical approaches and their outcomes in a single center.

Material And Methods: We retrospectively reviewed pediatric patients with CMs that were treated in our center between 2010 and 2020. Radiological, clinical, and demographic features, as well as treatment details were evaluated.

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Although endoscope-assisted techniques have been described, a full-endoscopic approach is yet to be performed for posterior fossa decompression (PFD) in Chiari malformation type I (CM-I). This study aims to describe the full-endoscopic PFD technique and evaluate its feasibility. Five fresh-frozen anonymized adult human cadavers were operated on using an endoscope with an oval shaft cross-section with a diameter of 9.

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Introduction: Relatively constant surgical risks and rapid advances in endovascular treatment have caused a major shift toward endovascular management of posterior circulation aneurysms. This paper presents the results of a series of endovascularly treated posterior circulation aneurysms.

Methods: A total of 81 patients who underwent endovascular treatment of posterior circulation aneurysms performed by a single team between 2009 and 2019 were included.

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Background: Supratentorial midline epidural hematoma is rare but challenging in diagnosis and management. Indication for surgery can arise even following hospital admission. Being familiar to the presentation and watching out for direct and indirect signs on axial computed tomography (CT) such as suture diastasis or fracture traversing midline are essential to plan multi-planar CT enabling exact diagnosis including form and mass effect of hematoma.

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Aim: To analyze and to compare the factors that influence the recurrence of chronic subdural hematoma (CSDH) among patients treated with subdural non-suction-assisted passive drainage, subgaleal suction-assisted active drainage, and without drainage.

Material And Methods: We retrospectively evaluated 87 surgical patients with a diagnosis of CSDH treated between 2007 and 2018 using patient records from the neurosurgery archive of our faculty. The patients were divided into three groups: drainfree group (group A), subdural passive drainage group (group B), and subgaleal active drainage group (group C).

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Aim: To evaluate isocitrate dehydrogenase (IDH) mutation status and Ki67 percentages of tumors that were treated in our institution to determine whether these markers affected the initial diagnosis and survival rates.

Material And Methods: High-grade glioma patients, who were operated in our department between 2013 and 2018, were enrolled in the study and retrospectively reviewed. New immunohistochemistry staining studies were conducted and survival analyses were performed.

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Aim: To present an early warning system (EWS) that employs a supervised machine learning algorithm for the rapid detection of extra-axial hematomas (EAHs) in an emergency trauma setting.

Material And Methods: A total of 150 sets of cranial computed tomography (CT) scans were used in this study with a total of 11,025 images. Of the CTs, 75 were labeled as EAH, the remaining 75 were normal.

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Aim: To demonstrate the feasibility of stent application to the third ventricular floor during endoscopic third ventriculostomy (ETV).

Material And Methods: We performed the ETV procedure on four fresh cadavers not exposed to head trauma. The neuroendoscope was introduced into the third ventricle under ultrasonography guidance.

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Background: Intraoperative ultrasound (iUS) is an effective guidance and imaging system commonly used in neuro-oncological surgery. Despite the versatility of iUS, its utility for single burr hole puncture guidance remains fairly underappreciated.

Objective: To highlight the simplicity, versatility, and effectiveness of iUS guidance in brain puncture by presenting the current case series and technical note collection.

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Objective: Normal pressure hydrocephalus (NPH) has clinical manifestations with different cognitive difficulties. Despite the intense interest, the change in cognitive functions after ventriculoperitoneal shunt (VPS) treatment varies widely. The aims of this study were to monitor the effect of NPH on cognition in elderly and the progress of cognitive abilities after VPS surgery.

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Background: Transsphenoidal endoscopic surgery is the first-line treatment for growth hormone-secreting adenomas.

Objective: To analyse the results of the transsphenoidal endoscopic approach for acromegaly and to determine the predictive factors of remission.

Methods: A single-centre retrospective review was performed in patients who underwent endoscopic transsphenoidal surgery for acromegaly between January 2009 and January 2019.

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