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Article Abstract
The aerial parts of Salvia clinopodioides afforded abietanes 1a, 2a, and 3 (clinopodiolides A-C), two of which possess an unusual lactol moiety at C-19-C-20, together with an icetexane named clinopodiolide D (4a). Their structures were established by spectroscopic means, mainly H and C NMR, including 1D and 2D homo- and heteronuclear experiments. The antioxidant, antiprotozoal, and antidiarrheal effects of the isolates were evaluated. Compounds 2a and 3 showed better effects than α-tocopherol in the inhibition of lipid peroxidation with IC (μM) = 5.9 ± 0.1 and 2.7 ± 0.2, respectively, and moderate activity in the DPPH assay. All tested compounds showed moderate antiamoebic and antigiardial activity, as well as a good antipropulsive effect.
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View Article and Find Full Text PDFStructure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides: Antioxidant, Antiprotozoal, and Antipropulsive Activities.
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Instituto de Química , Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Mexico City , 04510 Mexico.
Article Synopsis
- - The study isolated compounds 1a, 2a, and 3 (clinopodiolides A-C) as well as clinopodiolide D from the aerial parts of *Salvia clinopodioides*, which include unique structural features like a lactol moiety.
- - These compounds were analyzed using various spectroscopic techniques, primarily H and C NMR, to confirm their structures.
- - The isolates exhibited significant antioxidant properties, with compounds 2a and 3 outperforming α-tocopherol in lipid peroxidation inhibition and showing moderate antiamoebic, antigiardial, and antipropulsive effects.