Fluorescent chemosensing of epinephrine by a bis-boronic molecular receptor in aqueous media: crystal structure, spectroscopic studies and visual detection.

Selective recognition and sensing of neurotransmitters in aqueous media using artificial receptors is an attractive but challenging goal in modern supramolecular chemistry. Despite advances in the development of optical receptors for some neurotransmitters, such as dopamine, limited efforts have been invested in developing receptors for epinephrine, a neurotransmitter of paramount importance and a widely used drug for heart attacks. Herein, a new fluorescent molecular receptor (referred to as 1) based on a 1,3-bis-benzimidazole-benzene derivative covalently linked to two phenyl boronic acids was synthesized, structurally characterized single-crystal X-ray diffraction, and studied in-depth as a receptor for four catecholamine-based neurotransmitters as well as several nucleosides, monosaccharides and L-tyrosine in water at physiological pH.

The Antiproliferative Activity and NO Inhibition of -Clerodane Diterpenoids from in RAW 264.7 Macrophages.

In this study, nine -clerodane-type diterpenoids (-) were isolated from the dichloromethane extract of Bedolla & Zamudio leaves. Compounds - were new natural products, and - were acetone artifacts. In addition, four -clerodanes diterpenoids (-) previously described from different sources and six triterpenoids-identified as 3β,20,25-trihydroxylupane, oleanolic acid, 3β--acetyl-oleanolic acid, ursolic acid, 3β--acetyl-betulinic acid, and 3β,28--diacetyl-betulin-were isolated.

DMSO enhances the biosynthesis of epoxyquinols in sp. (strain IQ-011) and yields new [4 + 2] cycloaddition dimers.

sp. (strain IQ-011) produces cuautepestalorin (10), a 7,8-dihydrochromene-oxoisochromane adduct featuring a spiro-polycyclic (6/6/6/6/6/6) ring system. Additionally, it yields its proposed biosynthetic precursors: cytosporin M (1) and oxopestalochromane (11) when cultured under standard conditions (fermentation in solid media).

Tetranuclear and dinuclear Cu(II) complexes with risedronate as and agents. Synthesis, crystal structures, and biological evaluation.

The development of new biometal-based complexes containing antiparasitic bioactive ligands is a central field of coordination chemistry that impacts bioinorganic, medicinal, and biological chemistry. Herein, two novel water-soluble polynuclear Cu(II)-complexes with formula [Cu(4,4'-dmbp)(μ-HRis)Cl], 1 and [Cu(5,5'-dmbp)(μ-HRis)(HO)Cl] 2, (4,4'-dmbp = 4,4'-dimethyl-2,2'-bipyridine, 5,5'-dmbp = 5,5'-dimethyl-2,2'-bipyridine, HRis = risedronate), were synthesized by self-assembly solution reactions between the corresponding precursor complexes [Cu(dmbp)Cl] and the drug NaRis in aqueous media. Both Cu(II)-Ris complexes 1-2 were structurally described by single-crystal X-ray diffraction, characterized by spectroscopic tools (IR-ATR, HRMS, UV-Vis, EPR) and studied as antiparasitic agents against causative agent of Chagas disease and that is the etiological agent of cutaneous leishmaniasis.

New Fluorescent Chemodosimetric Mechanism for Selective Recognition of Selenocysteine by Dansyl-Appended Ruthenium Nitrosyl Complexes.

Selenocysteine (Sec) is a biologically essential amino acid that serves as a crucial component in selenoproteins that play a key role in various cellular functions. Thus, developing a reliable and rapid method for detecting Sec in physiological media is of paramount importance. This report introduces for the first time a novel fluorescent chemodosimetric mechanism for the selective recognition of Sec using dansyl-appended ruthenium nitrosyl complexes.