Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The ubiquitous human pathogens, herpes simplex virus (HSV)-1 and HSV-2, are distinct viral species that diverged approximately 6 million years ago. At least 4 small, ancient HSV-1 × HSV-2 interspecies recombination events have affected the HSV-2 genome, with recombinants and nonrecombinants at each locus circulating today. However, it is unknown whether interspecies recombination can affect other loci and whether new recombinants continue to be generated.
Methods: Using 255 newly sequenced and 230 existing HSV genome sequences, we comprehensively assessed interspecies recombination in HSV.
Results: Our findings show that the sizes and locations of interspecies recombination events in HSV-2 are significantly more variable than previously appreciated and that they can impact species-specific T-cell recognition of HSV.
Conclusions: We describe 2 large (>5 kb) recombination events, one of which arose in its current host, demonstrating that interspecies recombination continues to occur today. These results raise concerns about the use of live-attenuated HSV-2 vaccines in high HSV-1 prevalence areas.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325804 | PMC |
| http://dx.doi.org/10.1093/infdis/jiz199 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Halophilic heterotrophic ammonia assimilation biosystem shows stronger resilience and decreased ARGs abundance under sulfamethoxazole gradient stress compared with halophilic nitrification biosystem.
J Hazard Mater
September 2025
School of Civil Engineering, Shandong University, Jinan 250061, China; Laboratory of Water-Sediment Regulation and Eco-decontamination, Jinan 250061, China. Electronic address:
Differences of niche and nitrogen metabolism between halophilic nitrification (AN) and heterotrophic ammonia assimilation (HAA) biosystems determine microbiome resilience and antibiotic resistance genes (ARGs) transfer under antibiotic stress. However, the underlying mechanism of this difference remains unclear. This study compared the bioresponses and ARGs characteristics of the two biosystems under sulfamethoxazole (SMX) stress.
View Article and Find Full Text PDFAirborne human-associated ARGs in municipal wastewater treatment plants.
J Hazard Mater
September 2025
Beijing Engineering Research Center of Sustainable Urban Sewage System Construction and Risk Control, Beijing University of Civil Engineering and Architecture, Beijing 100044, PR China.
Antibiotic resistance genes (ARGs) in bioaerosols pose significant health hazards to humans because of their inhalability. Municipal wastewater treatment plants (MWTPs) are one of the typical sources of bioaerosol generation. However, there is a lack of clear understanding of human-associated ARGs (HA-ARGs) in bioaerosols from MWTPs.
View Article and Find Full Text PDFHorizontally transferred NADAR genes contribute to immune defense of ladybird beetles against bacterial infection.
Insect Biochem Mol Biol
September 2025
State Key Laboratory of Biocontrol, School of Ecology, Sun Yat-sen University, Shenzhen, China. Electronic address:
Horizontal gene transfer (HGT) is now widely recognized as an important mechanism contributing to host immunity and adaptation. Ladybird beetles, with their diverse diets and habitats, encounter a broad spectrum of microbial threats, making effective immune responses critical for their survival. However, the immune roles of HGT-acquired genes in ladybirds remain largely unexplored.
View Article and Find Full Text PDFHorizontal Gene Transfer and Recombination in Cyanobacteriota.
Annu Rev Microbiol
September 2025
4Institut Pasteur, Université Paris Cité, CNRS UMR3525, Microbial Evolutionary Genomics, Paris, France.
Cyanobacteria played a pivotal role in shaping Earth's early history and today are key players in many ecosystems. As versatile and ubiquitous phototrophs, they are used as models for oxygenic photosynthesis, nitrogen fixation, circadian rhythms, symbiosis, and adaptations to harsh environments. Cyanobacterial genomes and metagenomes exhibit high levels of genomic diversity partly driven by gene flow within and across species.
View Article and Find Full Text PDFNisin-like biosynthetic gene clusters are widely distributed across microbiomes.
mBio
September 2025
APC Microbiome Ireland, Biosciences Institute, Biosciences Research Institute, University College, Cork, Ireland.
Bacteriocins are antimicrobial peptides/proteins that can have narrow or broad inhibitory spectra and remarkable potency against clinically relevant pathogens. One such bacteriocin that is extensively used in the food industry and with potential for biotherapeutic application is the post-translationally modified peptide, nisin. Recent studies have shown the impact of nisin on the gastrointestinal microbiome, but relatively little is known of how abundant nisin production is in nature, the breadth of existing variants, and their antimicrobial potency.
View Article and Find Full Text PDF