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Calcium phosphate cement (CPC) has been studied extensively due to its bioactivity and biodegradability. CPC is typically made by a combination of multiple calcium phosphates that form a paste that sets and hardens in the body after being combined with either water or an aqueous solution. It is highly moldable and easily manipulated, and CPCs possess osteoconductive properties. Due to these characteristics, CPCs offer great promise in bone grafting applications. CPC combined with drugs has a great potential as drug delivery system and has been studied extensively. In this review we have focused on Bisphosphonate-CPC drug delivery system. In addition, we introduce and discuss the potential of studying other bisphosphonates.
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http://dx.doi.org/10.3233/BME-191055 | DOI Listing |
Environ Res
September 2025
School of Resources and Safety Engineering, University of Science and Technology Beijing, Beijing 100083, China; Key Laboratory of Safe and Green Mining of Metal Mines with Cemented Paste Backfill, National Mine Safety Administration, University of Science and Technology Beijing, Beijing 100083, Chi
Cemented paste backfill has made outstanding contributions to the large-scale consumption of phosphogypsum (PG), but poor water resistance significantly weakens the mechanical strength, promotes the leaching of total soluble phosphate (TP) and fluoride ions (F), and reduces its attractiveness in mine engineering. This research synthesized a curing agent (CA) using sodium methylsilicate, sodium silicate, and polyaluminum chloride (PAC). PG produced from Deyang Haohua Qingping Phosphate Mine Co.
View Article and Find Full Text PDFJ Mater Sci Mater Med
August 2025
Applied Chemistry Program, Graduate School of Science and Technology, Meiji University, Kawasaki, Japan.
Calcium-phosphate cement (CPC), a paste-like artificial bone, is a material form that allows minimally invasive treatment. However, CPC is not infection resistant, which may lead to surgical site infections. We recently developed a paste-like organic/inorganic hybrid artificial bone that is compatible with the bone remodeling cycle.
View Article and Find Full Text PDFVet Med Sci
September 2025
College of Animal Science &Technology, Nanjing Agricultural University, Nanjing, China.
The quality of pork has become an increasing concern for consumers, yet the impacts of floor types on meat quality remain insufficiently understood. This study aimed to compare the meat quality and muscle fibre characteristics of pigs raised on cement floors (CF) and deep litter floors (DF). Two large-scale pig farms were selected for the study: one with DF and one with CF.
View Article and Find Full Text PDFActa Biomater
August 2025
Department for Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany. Electronic address:
Calcium phosphate cements (CPCs) are widely used as medical devices for treating bone defects due to their high biocompatibility and ease of clinical application. Their porous structure and low setting temperature make them suitable as drug delivery systems, enabling high local drug concentrations while minimizing systemic side effects. However, successful application requires predictable drug release and a thorough understanding of drug-cement interactions.
View Article and Find Full Text PDFBioengineering (Basel)
July 2025
School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China.
Compared with biocompatibility, osteoconductivity, and mechanical properties, the poor injectability of calcium phosphate bone cements (CPCs) is always ignored, which actually hinders the development of CPC clinical transfer in minimally invasive orthopedic surgeries. Moreover, currently, CPC preparation in the clinic is labor-intensive and requires well-trained technicists, which might also result in the unstable quality of CPCs. In this work, we focused on three research objectives: (i) introducing a standardized preparation method for CPCs; (ii) studying the effects of preparation parameters on CPC injectability and compressive strength; and (iii) studying the injecting condition effects on CPC injectability, aiming to overcome CPCs' disadvantages in minimally invasive surgeries.
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