Rethinking the elusive boundaries of EBV-associated T/NK-cell lymphoproliferative disorders.

Haematologica

Department of Radiology, Huaxi Magnetic Resonance Research Centre (HMRRC), West China Hospital, Sichuan University, Chengdu

Published: March 2019


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395329PMC
http://dx.doi.org/10.3324/haematol.2018.215186DOI Listing

Publication Analysis

Top Keywords

rethinking elusive
4
elusive boundaries
4
boundaries ebv-associated
4
ebv-associated t/nk-cell
4
t/nk-cell lymphoproliferative
4
lymphoproliferative disorders
4
rethinking
1
boundaries
1
ebv-associated
1
t/nk-cell
1

Similar Publications

Sequestering organic carbon (OC) in soil encompasses complex abiotic and biotic processes that involve vegetation carbon (C) inputs, and following microbial-mediated transformations and mineral-organic associations, which are closely related to environmental constraints in climate change scenarios. Agroecosystems have substantial potential for sequestering OC in soil and thus mitigating climate change, through optimizing management strategies. However, the efficient strategies and underlying mechanisms to fulfill the potential remain largely elusive.

View Article and Find Full Text PDF

[Rethinking cancer].

Zhonghua Zhong Liu Za Zhi

June 2025

Department of Pathology, Shenzhen Third People's Hospital, the Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen 518112, China.

Over the past half-century of the global effort against cancer, the vast majority of investigations in both tumor basic research and clinical practice have centered on the "somatic mutation" theory, such as in molecular classification, individualized precision medicine strategies, gene therapy approaches, the development of neoantigen-based tumor vaccines, and advancements in sequencing technologies. Even in the extensively studied tumor microenvironment (including tumor immunity), which has garnered significant attention in recent years, the underlying mechanisms frequently revert to specific genes and mutations within tumor cells or microenvironmental cells as the primary driving forces. However, despite the dominance of the "somatic mutation" paradigm, truly effective approaches for curing cancer in clinical settings remain elusive.

View Article and Find Full Text PDF

Solutions to healthcare's most persistent and pervasive challenges remain elusive because we approach them as navigating oppositional tensions: the need to drive efficiency versus improve quality, to leverage cutting-edge technology versus maintain human compassion, to address population health versus providing care to the patient in front of you. The key to transforming healthcare lies in the ability of healthcare leaders to recognize when oppositional tensions are in fact paradoxes at play, to increase the capability and collective capacity to navigate them. Paradox science contends sustainable solutions to intractable challenges come not from eliminating the tensions that operate within the complexity but from the ability of those involved to hold opposing ideas in productive balance.

View Article and Find Full Text PDF

Rethinking the classification of non-digestible carbohydrates: Perspectives from the gut microbiome.

Compr Rev Food Sci Food Saf

November 2024

State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang, China.

Clarification is required when the term "carbohydrate" is used interchangeably with "saccharide" and "glycan." Carbohydrate classification based on human digestive enzyme activities brings clarity to the energy supply function of digestible sugars and starch. However, categorizing structurally diverse non-digestible carbohydrates (NDCs) to make dietary intake recommendations for health promotion remains elusive.

View Article and Find Full Text PDF

Rethinking life and predicting its origin.

Theory Biosci

September 2024

Centro de Química Estrutural and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisbon, Portugal.

The definition, origin and recreation of life remain elusive. As others have suggested, only once we put life into reductionist physical terms will we be able to solve those questions. To that end, this work proposes the phenomenon of life to be the product of two dissipative mechanisms.

View Article and Find Full Text PDF