Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Context: Despite its good prognosis, differentiated thyroid cancer (DTC) is characterized by high rates of disease persistence and recurrence. Estimation of long-term remission (excellent response) thanks to specific parameters could help to individualize the active surveillance schedule.
Objective: Evaluation of the ability of stimulated thyroglobulin (Tg) and Tg reduction index (TRI) to predict long-term remission in patients with DTC managed by thyroidectomy and radioactive iodine (RAI) remnant ablation.
Patients And Interventions: Observational retrospective study of 1093 patients treated for DTC between 1995 and 2010. Preablation stimulated thyroglobulin (presTg) was measured under thyroid hormone withdrawal just before RAI. Recombinant human TSH-stimulated thyroglobulin (sTg) was measured at first evaluation of the initial management 6 to 12 months after RAI. TRI was calculated based on pre-Tg and sTg.
Results: After univariate and multivariate analyses, lymph node invasion (N1, OR = 2.08; 95% CI, 1.19 to 3.64), presTg (OR = 4.04; 95% CI, 2.56 to 6.38), sTg (OR = 2.62; 95% CI, 2.05 to 3.34), and TRI (OR = 0.43; 95% CI, 0.21 to 0.88) were identified as independent prognostic factors influencing the rate of disease persistence or recurrence after the initial management. Receiver operating characteristic analysis identified presTg cutoff (<10 µg/L) to predict excellent response, with a negative predictive value of 94%, and validated for higher stages (T3/T4, N1). Furthermore, sTg <1 µg/L predicts excellent response. TRI >60% for the entire cohort and 62.5% for locally advanced disease (T3/T4, N1) was sensitive predictor for excellent response.
Conclusion: This study identifies presTg, sTg, and TRI as highly sensitive predictors of excellent response in patients with DTC and subsequently disease-free status. The cutoff of such parameters is also adapted for patients with higher tumor stages (T3/T4, N1).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/jc.2018-02680 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk factors and timing of postoperative hypothyroidism onset following hemithyroidectomy.
Auris Nasus Larynx
September 2025
Department of Otolaryngology, Tenri Hospital, Tenri, Nara, Japan.
Objective: This study aimed to identify prognostic factors for postoperative hypothyroidism and assess the timing of its onset in patients who underwent hemithyroidectomy for thyroid tumors. Despite normal preoperative thyroid function, some patients develop postoperative hypothyroidism, necessitating lifelong thyroid hormone replacement therapy. Identifying risk factors and establishing appropriate follow-up guidelines are essential for optimizing patient management.
View Article and Find Full Text PDFConstructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin.
Front Immunol
September 2025
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Introduction: Autoimmune thyroiditis (AIT) is a chronic autoimmune disease characterized by lymphocytic infiltration of the thyroid gland and elevated specific antibodies. Its incidence rises annually, yet no standardized animal model fully mimics human AIT. Given unclear pathogenesis and lack of targeted immunotherapies, researchers invest significant time in developing suitable models.
View Article and Find Full Text PDFDiagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma.
Front Immunol
September 2025
School of Medicine, Tarim University, Alaer, China.
Background: Over the past decade, the remarkable rise in differentiated thyroid carcinoma (DTC) incidence, combined with the limitations of conventional diagnostic approaches, have prompted this study to explore the diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value (PIV) for DTC, based on advancements in molecular biology and immunology.
Methods: Based on postoperative pathological diagnosis, the present retrospective research comprised 112 individuals afflicted with DTC (observation group) and 93 individuals having benign thyroid tumors (control group) from January 2023 to January 2025. Differences in clinical data between the two groups were analyzed via univariate statistical methods.
Atrophic hypothyroidism associated with thyrotropin receptor antibodies.
Einstein (Sao Paulo)
September 2025
Endocrinology Service, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Hypothyroidism is most frequently caused by Hashimoto's thyroiditis. While thyrotropin receptor antibodies are well-known in Graves' disease-induced hyperthyroidism, their role in hypothyroidism is emerging. We report the case of a 37-year-old woman with facial and periorbital edema, weight gain, and hoarseness suggestive of hypothyroidism.
View Article and Find Full Text PDFMultifocal papillary thyroid microcarcinomas: is the total tumor diameter associated with the tumor behavior? A retrospective cohort study.
Einstein (Sao Paulo)
September 2025
Internal Medicine Department, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.
Objective: To evaluate whether the total tumor diameter (sum of the largest diameters of all foci) predicts tumor aggressiveness at initial presentation and treatment response at 1-year follow-up in patients with multifocal papillary thyroid microcarcinoma.
Methods: A retrospective analysis was conducted on 475 patients with differentiated thyroid carcinoma. Fifty-two patients with multifocal papillary thyroid microcarcinoma were included.