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The aim of the present work was to develop a computational model of how children acquire inflectional morphology for marking person and number; one of the central challenges in language development. First, in order to establish which putative learning phenomena are sufficiently robust to constitute a target for modelling, we ran large-scale elicited production studies with native learners of Finnish (N = 77; 35-63 months) and Polish (N = 81; 35-59 months), using a novel method that, unlike previous studies, allows for elicitation of all six person/number forms in the paradigm (first, second and third person; singular and plural). We then proceeded to build and test a connectionist model of the acquisition of person/number marking which not only acquires near adult-like mastery of the system (including generalisation to unseen items), but also yields all of the key phenomena observed in the elicited-production studies; specifically, effects of token frequency and phonological neighbourhood density of the target form, and a pattern whereby errors generally reflect the replacement of low frequency targets by higher-frequency forms of the same verb, or forms with the same person/number as the target, but with a suffix from an inappropriate conjugation class. The findings demonstrate that acquisition of even highly complex systems of inflectional morphology can be accounted for by a theoretical model that assumes rote storage and phonological analogy, as opposed to formal symbolic rules.
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http://dx.doi.org/10.1016/j.cogpsych.2019.02.001 | DOI Listing |
Vet World
July 2025
Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya Street, Orenburg, 460000, Russia.
Background And Aim: The global demand for efficient poultry production necessitates alternatives to antibiotic growth promoters. This study aimed to evaluate the effects of a novel four-component organic-mineral feed additive (OMFA), comprising lactulose, arginine, ultrafine silicon dioxide particles, and succinic acid, and a three-component variant (without lactulose) on growth performance, nutrient digestibility, elemental tissue composition, and the cecal microbiota of Arbor Acres broiler chickens.
Materials And Methods: One hundred and five one-day-old broiler chicks were randomly allocated into three groups: Control, Group I (four-component OMFA), and Group II (three-component OMFA).
Curr Drug Discov Technol
September 2025
School of BioSciences and Technology, Vellore Institute of Technology, VIT University, Vellore, Tamil Nadu, India.
Introduction: Streptomyces species have complex genomes, including various biosynthetic gene clusters, frequently responsible for producing antibacterial and bioactive secondary metabolites under certain environmental conditions. To assess the impact of Magnesium and Iron on Streptomyces sp. VITGV100 secondary metabolite production and bioactivity, including molecular docking studies to predict their therapeutic potential.
View Article and Find Full Text PDFACS Nano
September 2025
National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Foot-and-mouth disease virus (FMDV), a critical pathogen in the global livestock industry, has long been a focal point of international disease control strategies. This study developed a nanoparticle-based FMDV vaccine platform. We fused the FMDV immunodominant epitope (VP1-G-H-loop) and T-cell epitope (T) with the nanoparticle scaffold (LS), efficiently producing the T-LS-LOOP nanoparticle vaccine using the prokaryotic expression system (BL21).
View Article and Find Full Text PDFHum Reprod
September 2025
Institut National de la Santé et de la Recherche Médicale, Ecole des Hautes Etudes en Santé Publique, Institut de recherche en santé, environnement et travail, Université de Rennes-UMR_S1085, Rennes, France.
Study Question: What is the direct effect of mumps virus (MuV) replication within the human testis on the tissue innate immune responses and testicular cell functions?
Summary Answer: MuV induces an early pro-inflammatory response in the human testis ex vivo and infects both Leydig cells and Sertoli cells, which drastically alters testosterone and inhibin B production.
What Is Known Already: Despite widespread vaccination efforts, orchitis remains a significant complication of MuV infection, especially in young men, which potentially results in infertility in up to 87% of patients with bilateral orchitis. Our understanding of MuV pathogenesis in the human testis has been limited by the lack of relevant animal models, impairing the development of effective treatments.
Crit Rev Food Sci Nutr
September 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
Natural products have emerged as a vital source of active ingredients in medicine, food, and cosmetics due to their unique biological activities, safety profiles, and sustainability. However, most bioactive compounds in natural products are intensely bitter, limiting their use in pharmaceuticals and foods. The bitter taste attributes vary markedly among different compound classes, predominantly due to their structural characteristics.
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