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http://dx.doi.org/10.1016/j.eururo.2019.01.031 | DOI Listing |
Oncol Res
September 2025
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Studies have reported the special value of PANoptosis in cancer, but there is no study on the prognostic and therapeutic effects of PANoptosis in bladder cancer (BLCA). This study aimed to explore the role of PANoptosis in BLCA heterogeneity and its impact on clinical outcomes and immunotherapy response while establishing a robust prognostic model based on PANoptosis-related features. Gene expression profiles and clinical data were collected from public databases.
View Article and Find Full Text PDFPract Radiat Oncol
September 2025
Department of Radiation Oncology, Institut Bergonié, Bordeaux, France; Centre de Radiothérapie Charlebourg, La Défense, Groupe Amethyst, 65, avenue Foch, 92250 La Garenne-Colombes, France.
Purpose: Urinary toxicity following radical prostatectomy (RP) and postoperative radiotherapy (RT) includes urinary incontinence and vesicourethral anastomosis (VUA) strictures. With the increasing use of stereotactic body radiotherapy (SBRT), dose-escalation, and reirradiation within the prostate bed (PB), standardization of the definition of urinary organs at risk (OARs) in the post-RP setting is needed. This works aims to provide a comprehensive review of the anatomical and physiopathological changes occurring after RP, as well as to provide a consensus on urinary OARs delineation for prostate cancer (PCa) EBRT in the post-RP setting.
View Article and Find Full Text PDFAJR Am J Roentgenol
September 2025
Department of Radiology, NYU Langone Health, New York, NY (H.A.V.).
Since its introduction in 2018, the Vesical Imaging Reporting and Data System (VI-RADS) has emerged as a standardized and reproducible framework for multiparametric MRI assessment of bladder cancer, with validated diagnostic accuracy in distinguishing muscle-invasive from non-muscle-invasive disease. Despite growing international interest, expert consensus, and the system's inclusion in most major guidelines, real-world clinical adoption of VI-RADS remains limited. This AJR Expert Panel Narrative Review explores the key barriers that hinder the implementation of VI-RADS into everyday workflows across diverse healthcare settings, including skepticism among referring clinicians, an inability (unlike cystoscopy-based staging) to perform simultaneous tumor resection, suboptimal posttreatment performance, and variability in image quality and reader experience.
View Article and Find Full Text PDFCurr Urol
September 2025
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.
Background: Although genetic variants associated with bladder cancer (BCa) risk have been identified through hypothesis-driven and genome-wide association studies, a systematic understanding of BCa genetic susceptibility at the gene and pathway levels remains to be achieved.
Materials And Methods: In this 2-stage functional genomics study, we used 5 independent tools for genome-wide gene mapping and ranking based on BCa genome-wide association studies summary statistics, followed by a meta-analysis of gene-level significance values, to obtain a consensus gene ranking in terms of association with BCa. Subsequently, we performed preranked gene-set enrichment analysis to identify the functional pathways involved in BCa genetic susceptibility.
Front Med (Lausanne)
August 2025
Department of Urology, Weifang People's Hospital, The First Clinical Medical College of Shandong Second Medical University, Weifang, China.
Urinary bladder paragangliomas (UBPs) are rare tumors of chromaffin tissue originating from the sympathetic innervation of the bladder wall. It constitutes less than 0.05% of bladder tumors and 0.
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